Amiodarone kinetics after single i.v. bolus and multiple dosing in healthy volunteers

E. Riva, L. Aarons, R. Latini, P. Neyroz, R. Urso

Research output: Contribution to journalArticle

Abstract

We studied three healthy volunteers after a single i.v. bolus of amiodarone, during 1 month of chronic oral dosing and after the discontinuation of the drug. Blood concentrations of amiodarone declined rapidly in a bi-exponential fashion after i.v. bolus. The terminal half-life ranged from 10 to 17 h; after discontinuation of chronic treatment the terminal half-lives were 8-21 days. The i.v. data, the trough levels during multiple dosing and the washout phase could be simultaneously fitted using a tri-exponential equation. The subjects were carefully monitored for cardiac and thyroid function. One subject had to stop taking amiodarone because of profound bradycardia. A reduction of serum TT3 and FT3 concentrations and an increase of serum rT3 and FT4 was found.

Original languageEnglish
Pages (from-to)491-494
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume27
Issue number4
DOIs
Publication statusPublished - Jul 1984

Keywords

  • amiodarone
  • kinetics
  • volunteers

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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