The tricyclic antidepressant amitriptyline is the drug of choice for the treatment of tension type headache (TH). Although it has been suggested that the analgesic effect of amitriptyline does not depend on its antidepressant activity, the effect of amitriptyline in non depressed TH patients has not been studied so far. We performed a randomized, parallel study to compare the efficacy and tolerability of amitriptyline at different doses (10, 25, 50 mg/day) in nondepressed patients with either chronic or episodic TH. Amitriptyline significantly reduced both frequency and duration of headache in chronic but not in episodic TH. Side effects were dose and time related. Analgesic activity of amitriptyline is not necessarily linked to its antidepressant activity. Furthermore the lack of efficacy of amitriptyline in episodic TH probably reflects the different pathogenesis of episodic and chronic TH.
|Translated title of the contribution||Amitriptyline therapy in the prevention of tension headache and its efficacy in non depressive patients with chronic or episodic headache|
|Number of pages||7|
|Publication status||Published - 1996|
ASJC Scopus subject areas
- Clinical Neurology