AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens

M. Vanoli, R. Scorza Smeraldi, G. Fabio, P. Bonara, M. G. Sabbadini, C. Zanussi

Research output: Contribution to journalArticlepeer-review

Abstract

We have examined the allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR) stimulating activities of T cells precultured in vitro with soluble allogeneic or autologous HLA-DR antigens. These cells (T(s)) are known to suppress the human MLR: this suppression is specific in that it occurs only when stimulator cells have the same HLA-DR antigen as that used to induce differentiation of suppressor cells. T(s) cells express new membrane specificities; they can be separated by immunoabsorption into two populations: T(s) enriched (T(x)+; with suppressive activity) and T(s) depleted (T(s)-; with helper function). In the present study, we have demonstrated that both T(s) cell subsets activated by soluble HLA-DR alloantigens are able to stimulate both MLR and AMLR. T(s) cells activated by soluble HLA-DR antigens are able to stimulate MLR, but not AMLR.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalClinical and Experimental Immunology
Volume63
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens'. Together they form a unique fingerprint.

Cite this