AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens

M. Vanoli, R. Scorza Smeraldi, G. Fabio, P. Bonara, M. G. Sabbadini, C. Zanussi

Research output: Contribution to journalArticle

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Abstract

We have examined the allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR) stimulating activities of T cells precultured in vitro with soluble allogeneic or autologous HLA-DR antigens. These cells (T(s)) are known to suppress the human MLR: this suppression is specific in that it occurs only when stimulator cells have the same HLA-DR antigen as that used to induce differentiation of suppressor cells. T(s) cells express new membrane specificities; they can be separated by immunoabsorption into two populations: T(s) enriched (T(x)+; with suppressive activity) and T(s) depleted (T(s)-; with helper function). In the present study, we have demonstrated that both T(s) cell subsets activated by soluble HLA-DR alloantigens are able to stimulate both MLR and AMLR. T(s) cells activated by soluble HLA-DR antigens are able to stimulate MLR, but not AMLR.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalClinical and Experimental Immunology
Volume63
Issue number1
Publication statusPublished - 1986

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Mixed Lymphocyte Culture Test
HLA-DR Antigens
Human Activities
T-Lymphocytes
Isoantigens
Autoantigens
T-Lymphocyte Subsets
In Vitro Techniques
Cell Differentiation
Membranes
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Vanoli, M., Scorza Smeraldi, R., Fabio, G., Bonara, P., Sabbadini, M. G., & Zanussi, C. (1986). AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens. Clinical and Experimental Immunology, 63(1), 163-170.

AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens. / Vanoli, M.; Scorza Smeraldi, R.; Fabio, G.; Bonara, P.; Sabbadini, M. G.; Zanussi, C.

In: Clinical and Experimental Immunology, Vol. 63, No. 1, 1986, p. 163-170.

Research output: Contribution to journalArticle

Vanoli, M, Scorza Smeraldi, R, Fabio, G, Bonara, P, Sabbadini, MG & Zanussi, C 1986, 'AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens', Clinical and Experimental Immunology, vol. 63, no. 1, pp. 163-170.
Vanoli M, Scorza Smeraldi R, Fabio G, Bonara P, Sabbadini MG, Zanussi C. AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens. Clinical and Experimental Immunology. 1986;63(1):163-170.
Vanoli, M. ; Scorza Smeraldi, R. ; Fabio, G. ; Bonara, P. ; Sabbadini, M. G. ; Zanussi, C. / AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens. In: Clinical and Experimental Immunology. 1986 ; Vol. 63, No. 1. pp. 163-170.
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