We have examined the allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR) stimulating activities of T cells precultured in vitro with soluble allogeneic or autologous HLA-DR antigens. These cells (T(s)) are known to suppress the human MLR: this suppression is specific in that it occurs only when stimulator cells have the same HLA-DR antigen as that used to induce differentiation of suppressor cells. T(s) cells express new membrane specificities; they can be separated by immunoabsorption into two populations: T(s) enriched (T(x)+; with suppressive activity) and T(s) depleted (T(s)-; with helper function). In the present study, we have demonstrated that both T(s) cell subsets activated by soluble HLA-DR alloantigens are able to stimulate both MLR and AMLR. T(s) cells activated by soluble HLA-DR antigens are able to stimulate MLR, but not AMLR.
|Number of pages||8|
|Journal||Clinical and Experimental Immunology|
|Publication status||Published - 1986|
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