Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series

M. Floridia, G. Masuelli, M. A. Meloni, I. Cetin, E. Tamburrini, A. F. Cavaliere, S. Dalzero, M. Sansone, S Alberico, B. Guerra, A Spinillo, Michela Chiadò Fiorio Tin, M. Ravizza, Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy, Alessandro Capone, Carmela Pinnetti, Giuseppina Liuzzi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.

DESIGN: Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.

SETTING: University and hospital clinics.

POPULATION: Pregnant women with HIV.

METHODS: Temporal trends were analysed by analysis of variance and by the Chi-square test for trend. Quantitative variables were compared by Student's t-test and categorical data by the Chi-square test, with odds ratios and 95% confidence intervals calculated.

MAIN OUTCOME MEASURES: Rate of invasive testing, intrauterine death, HIV transmission.

RESULTS: Between 2001 and 2015, among 2065 pregnancies in women with HIV, 113 (5.5%) had invasive tests performed. The procedures were conducted under antiretroviral treatment in 99 cases (87.6%), with a significant increase over time in the proportion of tests performed under highly active antiretroviral therapy (HAART) (100% in 2011-2015). Three intrauterine deaths were observed (2.6%), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis (n = 75), CVS (n = 12), or both (n = 1), two HIV transmissions occurred (2.3%). No HIV transmission occurred among the women who were on HAART at the time of invasive testing, and none after 2005.

CONCLUSIONS: The findings reinforce the assumption that invasive prenatal testing does not increase the risk of HIV vertical transmission among pregnant women under suppressive antiretroviral treatment.

TWEETABLE ABSTRACT: No HIV transmission occurred among women who underwent amniocentesis or CVS under effective anti-HIV regimens.

Original languageEnglish
JournalBJOG: An International Journal of Obstetrics and Gynaecology
DOIs
Publication statusE-pub ahead of print - Jun 20 2016

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Chorionic Villi Sampling
Amniocentesis
Pregnant Women
HIV
Highly Active Antiretroviral Therapy
Chi-Square Distribution
Pregnancy
Observational Studies
HIV-1
Analysis of Variance
Therapeutics
Odds Ratio
Newborn Infant
Confidence Intervals
Students

Keywords

  • Journal Article

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Amniocentesis and chorionic villus sampling in HIV-infected pregnant women : a multicentre case series. / Floridia, M.; Masuelli, G.; Meloni, M. A.; Cetin, I.; Tamburrini, E.; Cavaliere, A. F.; Dalzero, S.; Sansone, M.; Alberico, S; Guerra, B.; Spinillo, A; Chiadò Fiorio Tin, Michela; Ravizza, M.; Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy ; Capone, Alessandro; Pinnetti, Carmela; Liuzzi, Giuseppina.

In: BJOG: An International Journal of Obstetrics and Gynaecology, 20.06.2016.

Research output: Contribution to journalArticle

Floridia, M, Masuelli, G, Meloni, MA, Cetin, I, Tamburrini, E, Cavaliere, AF, Dalzero, S, Sansone, M, Alberico, S, Guerra, B, Spinillo, A, Chiadò Fiorio Tin, M, Ravizza, M, Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy, Capone, A, Pinnetti, C & Liuzzi, G 2016, 'Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series', BJOG: An International Journal of Obstetrics and Gynaecology. https://doi.org/10.1111/1471-0528.14183
Floridia, M. ; Masuelli, G. ; Meloni, M. A. ; Cetin, I. ; Tamburrini, E. ; Cavaliere, A. F. ; Dalzero, S. ; Sansone, M. ; Alberico, S ; Guerra, B. ; Spinillo, A ; Chiadò Fiorio Tin, Michela ; Ravizza, M. ; Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy ; Capone, Alessandro ; Pinnetti, Carmela ; Liuzzi, Giuseppina. / Amniocentesis and chorionic villus sampling in HIV-infected pregnant women : a multicentre case series. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2016.
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abstract = "OBJECTIVES: To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.DESIGN: Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.SETTING: University and hospital clinics.POPULATION: Pregnant women with HIV.METHODS: Temporal trends were analysed by analysis of variance and by the Chi-square test for trend. Quantitative variables were compared by Student's t-test and categorical data by the Chi-square test, with odds ratios and 95{\%} confidence intervals calculated.MAIN OUTCOME MEASURES: Rate of invasive testing, intrauterine death, HIV transmission.RESULTS: Between 2001 and 2015, among 2065 pregnancies in women with HIV, 113 (5.5{\%}) had invasive tests performed. The procedures were conducted under antiretroviral treatment in 99 cases (87.6{\%}), with a significant increase over time in the proportion of tests performed under highly active antiretroviral therapy (HAART) (100{\%} in 2011-2015). Three intrauterine deaths were observed (2.6{\%}), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis (n = 75), CVS (n = 12), or both (n = 1), two HIV transmissions occurred (2.3{\%}). No HIV transmission occurred among the women who were on HAART at the time of invasive testing, and none after 2005.CONCLUSIONS: The findings reinforce the assumption that invasive prenatal testing does not increase the risk of HIV vertical transmission among pregnant women under suppressive antiretroviral treatment.TWEETABLE ABSTRACT: No HIV transmission occurred among women who underwent amniocentesis or CVS under effective anti-HIV regimens.",
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T1 - Amniocentesis and chorionic villus sampling in HIV-infected pregnant women

T2 - a multicentre case series

AU - Floridia, M.

AU - Masuelli, G.

AU - Meloni, M. A.

AU - Cetin, I.

AU - Tamburrini, E.

AU - Cavaliere, A. F.

AU - Dalzero, S.

AU - Sansone, M.

AU - Alberico, S

AU - Guerra, B.

AU - Spinillo, A

AU - Chiadò Fiorio Tin, Michela

AU - Ravizza, M.

AU - Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy

AU - Capone, Alessandro

AU - Pinnetti, Carmela

AU - Liuzzi, Giuseppina

N1 - © 2016 Royal College of Obstetricians and Gynaecologists.

PY - 2016/6/20

Y1 - 2016/6/20

N2 - OBJECTIVES: To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.DESIGN: Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.SETTING: University and hospital clinics.POPULATION: Pregnant women with HIV.METHODS: Temporal trends were analysed by analysis of variance and by the Chi-square test for trend. Quantitative variables were compared by Student's t-test and categorical data by the Chi-square test, with odds ratios and 95% confidence intervals calculated.MAIN OUTCOME MEASURES: Rate of invasive testing, intrauterine death, HIV transmission.RESULTS: Between 2001 and 2015, among 2065 pregnancies in women with HIV, 113 (5.5%) had invasive tests performed. The procedures were conducted under antiretroviral treatment in 99 cases (87.6%), with a significant increase over time in the proportion of tests performed under highly active antiretroviral therapy (HAART) (100% in 2011-2015). Three intrauterine deaths were observed (2.6%), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis (n = 75), CVS (n = 12), or both (n = 1), two HIV transmissions occurred (2.3%). No HIV transmission occurred among the women who were on HAART at the time of invasive testing, and none after 2005.CONCLUSIONS: The findings reinforce the assumption that invasive prenatal testing does not increase the risk of HIV vertical transmission among pregnant women under suppressive antiretroviral treatment.TWEETABLE ABSTRACT: No HIV transmission occurred among women who underwent amniocentesis or CVS under effective anti-HIV regimens.

AB - OBJECTIVES: To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.DESIGN: Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.SETTING: University and hospital clinics.POPULATION: Pregnant women with HIV.METHODS: Temporal trends were analysed by analysis of variance and by the Chi-square test for trend. Quantitative variables were compared by Student's t-test and categorical data by the Chi-square test, with odds ratios and 95% confidence intervals calculated.MAIN OUTCOME MEASURES: Rate of invasive testing, intrauterine death, HIV transmission.RESULTS: Between 2001 and 2015, among 2065 pregnancies in women with HIV, 113 (5.5%) had invasive tests performed. The procedures were conducted under antiretroviral treatment in 99 cases (87.6%), with a significant increase over time in the proportion of tests performed under highly active antiretroviral therapy (HAART) (100% in 2011-2015). Three intrauterine deaths were observed (2.6%), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis (n = 75), CVS (n = 12), or both (n = 1), two HIV transmissions occurred (2.3%). No HIV transmission occurred among the women who were on HAART at the time of invasive testing, and none after 2005.CONCLUSIONS: The findings reinforce the assumption that invasive prenatal testing does not increase the risk of HIV vertical transmission among pregnant women under suppressive antiretroviral treatment.TWEETABLE ABSTRACT: No HIV transmission occurred among women who underwent amniocentesis or CVS under effective anti-HIV regimens.

KW - Journal Article

U2 - 10.1111/1471-0528.14183

DO - 10.1111/1471-0528.14183

M3 - Article

C2 - 27319948

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

ER -