Amniotic membrane chambers for pancreatic islet transplantation: The diffusion patterns of glucose and insulin

A. Maldonato, A. Cama, F. Marani

Research output: Contribution to journalArticlepeer-review

Abstract

Diffusion chambers (DC) made with semipermeable artificial membranes have been extensively used to protect transplanted pancreatic islet tissue from rejection. Their long-term failure is probably due to the host's foreign body reaction to the implant. Human amniotic membranes (AMs) have been used several times as grafts for various purposes. They are not rejected not do they induce a foreign body reaction, and they may stimulate neovascularization at the site of the implant. These characteristics of AM could make it a suitable material for enclosing islets, provided that its permeability is appropriate. In the present study, we tested in vitro the permeability of AM to 125I-insulin (INS), D-glucose (G), and human lymphocytes (Ls).

Original languageEnglish
Pages (from-to)146-147
Number of pages2
JournalTransplantation Proceedings
Volume17
Issue numberSUPPL. 2
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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