AMP-activated protein kinase: Structure, function, and role in pathological processes

D. S. Novikova, A. V. Garabadzhiu, G. Melino, N. A. Barlev, V. G. Tribulovich

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Recently, AMP-activated protein kinase (AMPK) has emerged as a key regulator of energy balance at cellular and whole-body levels. Due to the involvement in multiple signaling pathways, AMPK efficiently controls ATP-consuming/ATP-generating processes to maintain energy homeostasis under stress conditions. Loss of the kinase activity or attenuation of its expression leads to a variety of metabolic disorders and increases cancer risk. In this review, we discuss recent findings on the structure of AMPK, its activation mechanisms, as well as the consequences of its targets in regulation of metabolism. Particular attention is given to low-molecular-weight compounds that activate or inhibit AMPK; the perspective of therapeutic use of such modulators in treatment of several common diseases is discussed.

Original languageEnglish
Pages (from-to)127-144
Number of pages18
JournalBiochemistry (Moscow)
Volume80
Issue number2
DOIs
Publication statusPublished - 2015

Fingerprint

AMP-Activated Protein Kinases
Pathologic Processes
Adenosine Triphosphate
Therapeutic Uses
Energy balance
Metabolism
Modulators
Homeostasis
Phosphotransferases
Molecular Weight
Chemical activation
Molecular weight
Neoplasms

Keywords

  • AMP-activated protein kinase
  • AMPK activators
  • AMPK inhibitors
  • cancer
  • diabetes type 2
  • energy metabolism
  • metabolic syndrome

ASJC Scopus subject areas

  • Biochemistry

Cite this

AMP-activated protein kinase : Structure, function, and role in pathological processes. / Novikova, D. S.; Garabadzhiu, A. V.; Melino, G.; Barlev, N. A.; Tribulovich, V. G.

In: Biochemistry (Moscow), Vol. 80, No. 2, 2015, p. 127-144.

Research output: Contribution to journalArticle

Novikova, D. S. ; Garabadzhiu, A. V. ; Melino, G. ; Barlev, N. A. ; Tribulovich, V. G. / AMP-activated protein kinase : Structure, function, and role in pathological processes. In: Biochemistry (Moscow). 2015 ; Vol. 80, No. 2. pp. 127-144.
@article{37e1b548fafd432abd2a82e18c2f8964,
title = "AMP-activated protein kinase: Structure, function, and role in pathological processes",
abstract = "Recently, AMP-activated protein kinase (AMPK) has emerged as a key regulator of energy balance at cellular and whole-body levels. Due to the involvement in multiple signaling pathways, AMPK efficiently controls ATP-consuming/ATP-generating processes to maintain energy homeostasis under stress conditions. Loss of the kinase activity or attenuation of its expression leads to a variety of metabolic disorders and increases cancer risk. In this review, we discuss recent findings on the structure of AMPK, its activation mechanisms, as well as the consequences of its targets in regulation of metabolism. Particular attention is given to low-molecular-weight compounds that activate or inhibit AMPK; the perspective of therapeutic use of such modulators in treatment of several common diseases is discussed.",
keywords = "AMP-activated protein kinase, AMPK activators, AMPK inhibitors, cancer, diabetes type 2, energy metabolism, metabolic syndrome",
author = "Novikova, {D. S.} and Garabadzhiu, {A. V.} and G. Melino and Barlev, {N. A.} and Tribulovich, {V. G.}",
year = "2015",
doi = "10.1134/S0006297915020017",
language = "English",
volume = "80",
pages = "127--144",
journal = "Biochemistry. Biokhimiia",
issn = "0006-2979",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "2",

}

TY - JOUR

T1 - AMP-activated protein kinase

T2 - Structure, function, and role in pathological processes

AU - Novikova, D. S.

AU - Garabadzhiu, A. V.

AU - Melino, G.

AU - Barlev, N. A.

AU - Tribulovich, V. G.

PY - 2015

Y1 - 2015

N2 - Recently, AMP-activated protein kinase (AMPK) has emerged as a key regulator of energy balance at cellular and whole-body levels. Due to the involvement in multiple signaling pathways, AMPK efficiently controls ATP-consuming/ATP-generating processes to maintain energy homeostasis under stress conditions. Loss of the kinase activity or attenuation of its expression leads to a variety of metabolic disorders and increases cancer risk. In this review, we discuss recent findings on the structure of AMPK, its activation mechanisms, as well as the consequences of its targets in regulation of metabolism. Particular attention is given to low-molecular-weight compounds that activate or inhibit AMPK; the perspective of therapeutic use of such modulators in treatment of several common diseases is discussed.

AB - Recently, AMP-activated protein kinase (AMPK) has emerged as a key regulator of energy balance at cellular and whole-body levels. Due to the involvement in multiple signaling pathways, AMPK efficiently controls ATP-consuming/ATP-generating processes to maintain energy homeostasis under stress conditions. Loss of the kinase activity or attenuation of its expression leads to a variety of metabolic disorders and increases cancer risk. In this review, we discuss recent findings on the structure of AMPK, its activation mechanisms, as well as the consequences of its targets in regulation of metabolism. Particular attention is given to low-molecular-weight compounds that activate or inhibit AMPK; the perspective of therapeutic use of such modulators in treatment of several common diseases is discussed.

KW - AMP-activated protein kinase

KW - AMPK activators

KW - AMPK inhibitors

KW - cancer

KW - diabetes type 2

KW - energy metabolism

KW - metabolic syndrome

UR - http://www.scopus.com/inward/record.url?scp=84923331803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923331803&partnerID=8YFLogxK

U2 - 10.1134/S0006297915020017

DO - 10.1134/S0006297915020017

M3 - Article

C2 - 25756529

AN - SCOPUS:84923331803

VL - 80

SP - 127

EP - 144

JO - Biochemistry. Biokhimiia

JF - Biochemistry. Biokhimiia

SN - 0006-2979

IS - 2

ER -