AMP-activated protein kinase: Structure, function, and role in pathological processes

D. S. Novikova, A. V. Garabadzhiu, G. Melino, N. A. Barlev, V. G. Tribulovich

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, AMP-activated protein kinase (AMPK) has emerged as a key regulator of energy balance at cellular and whole-body levels. Due to the involvement in multiple signaling pathways, AMPK efficiently controls ATP-consuming/ATP-generating processes to maintain energy homeostasis under stress conditions. Loss of the kinase activity or attenuation of its expression leads to a variety of metabolic disorders and increases cancer risk. In this review, we discuss recent findings on the structure of AMPK, its activation mechanisms, as well as the consequences of its targets in regulation of metabolism. Particular attention is given to low-molecular-weight compounds that activate or inhibit AMPK; the perspective of therapeutic use of such modulators in treatment of several common diseases is discussed.

Original languageEnglish
Pages (from-to)127-144
Number of pages18
JournalBiochemistry (Moscow)
Volume80
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • AMP-activated protein kinase
  • AMPK activators
  • AMPK inhibitors
  • cancer
  • diabetes type 2
  • energy metabolism
  • metabolic syndrome

ASJC Scopus subject areas

  • Biochemistry

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