Amphetamine and fenfluramine, two drugs for studies on food intake

S. Garattini, R. Samanin

Research output: Contribution to journalArticle


Amphetamine and fenfluramine, although structurally related, have quite different properties on both the experimental and clinical planes and even their common ability to decrease food intake appears to depend on different mechanisms. The neurochemical effects of amphetamine and fenfluramine are somewhat different since the former interacts mainly with brain catecholamines while the latter has a marked effect on the serotoninergic system. Even when the two durgs produce the same biochemical effect, the mechanisms involved may be different. The activity of amphetamine appears to be mediated by central catecholaminergic neurons, whereas integrity of the central serotoninergic system is important if fenfluramine is to exert full anorectic activity. These and other differences between the two drugs suggest that they might constitute two prototypes for investigating food intake regulatory mechanisms. The search for direct or indirect central serotonergic agonists may provide some fruitful leads to new, effective, and possibly non-addictive agents for decreasing food intake.

Original languageEnglish
Pages (from-to)349-351
Number of pages3
JournalInternational Journal of Obesity
Issue number3
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

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