Amsterdam criteria II and endometrial cancer index cases for an accurate selection of HNPCC families

Mara Fornasarig, Alessandra Viel, Ettore Bidoli, Elio Campagnutta, Alessandro Marco Minisini, Renato Cannizzaro, Lara Della Puppa, Mauro Boiocchi

Research output: Contribution to journalArticlepeer-review

Abstract

Endometrial carcinoma (EC) is the second most common tumor in hereditary nonpolyposis colorectal cancer (HNPCC), with an incidence rate of 60% by the age of 70 in mutation carriers. The International Collaborative Group on HNPCC revised the Amsterdam criteria and proposed a new, wider definition including extracolonic cancers. The aim of our study was to evaluate the accuracy of a new definition called Amsterdam criteria II. We updated, reclassified and compared the pedigrees of 29 women, already reported as being affected by EC and having a colorectal cancer familial background, according to the two clinical diagnostic criteria for HNPCC (Amsterdam criteria I, ACI, and Amsterdam criteria II, ACII) after two periods of observation (1990-1995 and 1995-2000). According to ACII the frequency of HNPCC in the population under study increased from 0.9% to 3.7% in the period 1990-1995 and from 3.2% to 3.7% in the period 1995-2000. ACII allowed early detection of HNPCC families and thus made it possible to provide them with a suitable surveillance program and genetic testing.

Original languageEnglish
Pages (from-to)18-20
Number of pages3
JournalTumori
Volume88
Issue number1
Publication statusPublished - 2002

Keywords

  • Amsterdam criteria
  • Endometrial carcinoma
  • HNPCC
  • Mismatch repair genes

ASJC Scopus subject areas

  • Cancer Research

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