Amygdala and dorsal hippocampus lesions block the effects of GABAergic drugs on memory storage

Martine Ammassari-Teule, Flaminia Pavone, Claudio Castellano, James L. McGaugh

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

These experiments examined the effects of posttraining systemic administration of the GABAergic agonist muscimol and the GABAergic antagonist bicuculline on retention in mice with bilateral lesions of the amygdala, dorsal hippocampus or caudate nucleus. Unoperated male CD1 mice and mice with either sham lesions or electrolytically induced lesions of these 3 brain regions were trained in a one-trial inhibitory avoidance task and, immediately after training, received i.p. injections of either muscimol, (1.0, 2.0 or 3.0 mg/kg), bicuculline, (0.25, 0.5 or 1.0 mg/kg), or control solutions. Retention was tested 24 h after training. Lesions of the 3 brain regions produced comparable impairment of retention. In the unoperated controls and sham controls muscimol and bicuculline produced dose-dependent impairment and enhancement, respectively, of retention. The drug effects on retention were blocked by lesions of the amygdala and hippocampus, but were not blocked by lesions of the caudate nucleus. These findings are consistent with other recent evidence suggesting that the amygdala and hippocampus are involved in mediating posttraining neuromodulatory influences on memory storage.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalBrain Research
Volume551
Issue number1-2
DOIs
Publication statusPublished - Jun 14 1991

Fingerprint

Amygdala
Hippocampus
Muscimol
Bicuculline
Pharmaceutical Preparations
Caudate Nucleus
Brain
Retention (Psychology)
Injections

Keywords

  • Amygdala
  • Bicuculline
  • Caudate
  • Hippocampus
  • Inhibitory avoidance
  • Lesion
  • Memory
  • Muscimol

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Amygdala and dorsal hippocampus lesions block the effects of GABAergic drugs on memory storage. / Ammassari-Teule, Martine; Pavone, Flaminia; Castellano, Claudio; McGaugh, James L.

In: Brain Research, Vol. 551, No. 1-2, 14.06.1991, p. 104-109.

Research output: Contribution to journalArticle

Ammassari-Teule, M, Pavone, F, Castellano, C & McGaugh, JL 1991, 'Amygdala and dorsal hippocampus lesions block the effects of GABAergic drugs on memory storage', Brain Research, vol. 551, no. 1-2, pp. 104-109. https://doi.org/10.1016/0006-8993(91)90919-M
Ammassari-Teule, Martine ; Pavone, Flaminia ; Castellano, Claudio ; McGaugh, James L. / Amygdala and dorsal hippocampus lesions block the effects of GABAergic drugs on memory storage. In: Brain Research. 1991 ; Vol. 551, No. 1-2. pp. 104-109.
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