Abstract
MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies.
| Original language | English |
|---|---|
| Pages (from-to) | 1882-1891 |
| Number of pages | 10 |
| Journal | Cell Reports |
| Volume | 17 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Nov 8 2016 |
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Keywords
- Ago2
- amygdala
- anxiety
- childhood trauma
- chronic stress
- early life stress
- FKBP5
- microRNA-15a
- stress adaption
- stress-related psychopathologies
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress. / Volk, Naama; Pape, Julius C.; Engel, Mareen; Zannas, Anthony S.; Cattane, Nadia; Cattaneo, Annamaria; Binder, Elisabeth B.; Chen, Alon.
In: Cell Reports, Vol. 17, No. 7, 08.11.2016, p. 1882-1891.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress
AU - Volk, Naama
AU - Pape, Julius C.
AU - Engel, Mareen
AU - Zannas, Anthony S.
AU - Cattane, Nadia
AU - Cattaneo, Annamaria
AU - Binder, Elisabeth B.
AU - Chen, Alon
PY - 2016/11/8
Y1 - 2016/11/8
N2 - MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies.
AB - MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies.
KW - Ago2
KW - amygdala
KW - anxiety
KW - childhood trauma
KW - chronic stress
KW - early life stress
KW - FKBP5
KW - microRNA-15a
KW - stress adaption
KW - stress-related psychopathologies
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UR - http://www.scopus.com/inward/citedby.url?scp=84994400059&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2016.10.038
DO - 10.1016/j.celrep.2016.10.038
M3 - Article
VL - 17
SP - 1882
EP - 1891
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 7
ER -