Amyloid-β dynamics correlate with neurological status in the injured human brain

David L. Brody, Sandra Magnoni, Kate E. Schwetye, Michael L. Spinner, Thomas J. Esparza, Nino Stocchetti, Gregory J. Zipfel, David M. Holtzman

Research output: Contribution to journalArticlepeer-review

Abstract

The amyloid-β peptide (Aβ) plays a central pathophysiological role in Alzheimer's disease, but little is known about the concentration and dynamics of this secreted peptide in the extracellular space of the human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were undergoing invasive intracranial monitoring after acute brain injury. We found a strong positive correlation between changes in brain ISF Aβ concentrations and neurological status, with Aβ concentrations increasing as neurological status improved and falling when neurological status declined. Brain ISF Aβ concentrations were also lower when other cerebral physiological and metabolic abnormalities reflected depressed neuronal function. Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Aβ concentration.

Original languageEnglish
Pages (from-to)1221-1224
Number of pages4
JournalScience
Volume321
Issue number5893
DOIs
Publication statusPublished - Aug 29 2008

ASJC Scopus subject areas

  • General

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