Amyloid β peptide promotes differentiation of pro-inflammatory human myeloid dendritic cells

Antonio Ciaramella, Nunzia Sanarico, Federica Bizzoni, Maria Luisa Moro, Francesca Salani, Giuseppe Scapigliati, Gianfranco Spalletta, Carlo Caltagirone, Paola Bossù

Research output: Contribution to journalArticle

Abstract

A key event of Alzheimer's disease (AD) pathogenesis is the production of amyloid β peptides (Aβ), which are hypothesized to lead to neurodegeneration by still unclear mechanisms, including a chronic inflammatory response characterized by innate immune cell activation and pro-inflammatory molecule release. Since dendritic cells (DCs) are central players of innate immune response and brain dendritic-like cells may have a crucial role in AD pathogenesis, this study investigates the effects of Aβ on human DC functions. Myeloid DCs differentiated in the presence of Aβ42 showed an increase in survival and soluble antigen uptake, a reduction in HLA molecule expression and in IL-10 and IL-12 production. Accordingly, Aβ42-treated DCs were impaired in inducing T cell proliferation and IL-2 production. On the other hand, Aβ42 treatment provided DCs with the ability to release higher levels of IL-1β, IL-6 and IL-18, than control DCs. These results demonstrate that Aβ42 can modulate the immune system by inducing pro-inflammatory DC differentiation, thus gaining new insights into AD pathogenesis and immune-based therapeutic intervention.

Original languageEnglish
Pages (from-to)210-221
Number of pages12
JournalNeurobiology of Aging
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Myeloid Cells
Amyloid
Dendritic Cells
Peptides
Alzheimer Disease
Innate Immunity
Interleukin-18
Aptitude
Interleukin-12
Interleukin-1
Interleukin-10
Interleukin-2
Cell Differentiation
Immune System
Interleukin-6
Cell Proliferation
T-Lymphocytes
Antigens
Survival
Brain

Keywords

  • Alzheimer's disease (AD)
  • Amyloid β peptide (Aβ42)
  • Dendritic cells (DCs)
  • Inflammation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Amyloid β peptide promotes differentiation of pro-inflammatory human myeloid dendritic cells. / Ciaramella, Antonio; Sanarico, Nunzia; Bizzoni, Federica; Moro, Maria Luisa; Salani, Francesca; Scapigliati, Giuseppe; Spalletta, Gianfranco; Caltagirone, Carlo; Bossù, Paola.

In: Neurobiology of Aging, Vol. 30, No. 2, 02.2009, p. 210-221.

Research output: Contribution to journalArticle

Ciaramella, Antonio ; Sanarico, Nunzia ; Bizzoni, Federica ; Moro, Maria Luisa ; Salani, Francesca ; Scapigliati, Giuseppe ; Spalletta, Gianfranco ; Caltagirone, Carlo ; Bossù, Paola. / Amyloid β peptide promotes differentiation of pro-inflammatory human myeloid dendritic cells. In: Neurobiology of Aging. 2009 ; Vol. 30, No. 2. pp. 210-221.
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