Abstract
Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-β-{40} (Aβ-{40}) and Aβ-{42} in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Aβ-{42}, as well as the Aβ-{42}/Aβ-{40} ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Aβ-{42} and, to a lesser extent, Aβ-{40} than the stable cases. However the large variability of measured values indicates that plasma Aβ is not a suitable marker of incipient AD.
| Original language | English |
|---|---|
| Pages (from-to) | 267-271 |
| Number of pages | 5 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Alzheimer's disease
- Amyloid-β
- Mild cognitive impairment
- Plasma
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology
- Medicine(all)
Cite this
Amyloid-β42 plasma levels are elevated in amnestic mild cognitive impairment. / Cammarata, Sergio; Borghi, Roberta; Giliberto, Luca; Pardini, Matteo; Pollero, Valeria; Novello, Cristina; Fornaro, Michele; Vitali, Antonella; Bracco, Laura; Caltagirone, Carlo; Bossù, Paola; Odetti, Patrizio; Tabaton, Massimo.
In: Journal of Alzheimer's Disease, Vol. 18, No. 2, 2009, p. 267-271.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amyloid-β42 plasma levels are elevated in amnestic mild cognitive impairment
AU - Cammarata, Sergio
AU - Borghi, Roberta
AU - Giliberto, Luca
AU - Pardini, Matteo
AU - Pollero, Valeria
AU - Novello, Cristina
AU - Fornaro, Michele
AU - Vitali, Antonella
AU - Bracco, Laura
AU - Caltagirone, Carlo
AU - Bossù, Paola
AU - Odetti, Patrizio
AU - Tabaton, Massimo
PY - 2009
Y1 - 2009
N2 - Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-β-{40} (Aβ-{40}) and Aβ-{42} in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Aβ-{42}, as well as the Aβ-{42}/Aβ-{40} ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Aβ-{42} and, to a lesser extent, Aβ-{40} than the stable cases. However the large variability of measured values indicates that plasma Aβ is not a suitable marker of incipient AD.
AB - Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-β-{40} (Aβ-{40}) and Aβ-{42} in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Aβ-{42}, as well as the Aβ-{42}/Aβ-{40} ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Aβ-{42} and, to a lesser extent, Aβ-{40} than the stable cases. However the large variability of measured values indicates that plasma Aβ is not a suitable marker of incipient AD.
KW - Alzheimer's disease
KW - Amyloid-β
KW - Mild cognitive impairment
KW - Plasma
UR - http://www.scopus.com/inward/record.url?scp=70350492757&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350492757&partnerID=8YFLogxK
U2 - 10.3233/JAD-2009-1144
DO - 10.3233/JAD-2009-1144
M3 - Article
C2 - 19584444
AN - SCOPUS:70350492757
VL - 18
SP - 267
EP - 271
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -