Amyloid-β42 plasma levels are elevated in amnestic mild cognitive impairment

Sergio Cammarata; Roberta Borghi; Luca Giliberto; Matteo Pardini; Valeria Pollero; Cristina Novello; Michele Fornaro; Antonella Vitali; Laura Bracco; Carlo Caltagirone; Paola Bossù; Patrizio Odetti; Massimo Tabaton

doi:10.3233/JAD-2009-1144

Amyloid-β42 plasma levels are elevated in amnestic mild cognitive impairment

Sergio Cammarata, Roberta Borghi, Luca Giliberto, Matteo Pardini, Valeria Pollero, Cristina Novello, Michele Fornaro, Antonella Vitali, Laura Bracco, Carlo Caltagirone, Paola Bossù, Patrizio Odetti, Massimo Tabaton

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-β-{40} (Aβ-{40}) and Aβ-{42} in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Aβ-{42}, as well as the Aβ-{42}/Aβ-{40} ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Aβ-{42} and, to a lesser extent, Aβ-{40} than the stable cases. However the large variability of measured values indicates that plasma Aβ is not a suitable marker of incipient AD.

Original language	English
Pages (from-to)	267-271
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	18
Issue number	2
DOIs	https://doi.org/10.3233/JAD-2009-1144
Publication status	Published - 2009

Keywords

Alzheimer's disease
Amyloid-β
Mild cognitive impairment
Plasma

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Clinical Psychology
Medicine(all)

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Amyloid-β42 plasma levels are elevated in amnestic mild cognitive impairment. / Cammarata, Sergio; Borghi, Roberta; Giliberto, Luca; Pardini, Matteo; Pollero, Valeria; Novello, Cristina; Fornaro, Michele; Vitali, Antonella; Bracco, Laura; Caltagirone, Carlo ; Bossù, Paola; Odetti, Patrizio; Tabaton, Massimo.

In: Journal of Alzheimer's Disease, Vol. 18, No. 2, 2009, p. 267-271.

Research output: Contribution to journal › Article › peer-review

Cammarata, Sergio ; Borghi, Roberta ; Giliberto, Luca ; Pardini, Matteo ; Pollero, Valeria ; Novello, Cristina ; Fornaro, Michele ; Vitali, Antonella ; Bracco, Laura ; Caltagirone, Carlo ; Bossù, Paola ; Odetti, Patrizio ; Tabaton, Massimo. / Amyloid-β42 plasma levels are elevated in amnestic mild cognitive impairment. In: Journal of Alzheimer's Disease. 2009 ; Vol. 18, No. 2. pp. 267-271.

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abstract = "Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-β-{40} (Aβ-{40}) and Aβ-{42} in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Aβ-{42}, as well as the Aβ-{42}/Aβ-{40} ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Aβ-{42} and, to a lesser extent, Aβ-{40} than the stable cases. However the large variability of measured values indicates that plasma Aβ is not a suitable marker of incipient AD.",

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