TY - JOUR
T1 - Amyloid-β42 plasma levels are elevated in amnestic mild cognitive impairment
AU - Cammarata, Sergio
AU - Borghi, Roberta
AU - Giliberto, Luca
AU - Pardini, Matteo
AU - Pollero, Valeria
AU - Novello, Cristina
AU - Fornaro, Michele
AU - Vitali, Antonella
AU - Bracco, Laura
AU - Caltagirone, Carlo
AU - Bossù, Paola
AU - Odetti, Patrizio
AU - Tabaton, Massimo
PY - 2009
Y1 - 2009
N2 - Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-β-{40} (Aβ-{40}) and Aβ-{42} in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Aβ-{42}, as well as the Aβ-{42}/Aβ-{40} ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Aβ-{42} and, to a lesser extent, Aβ-{40} than the stable cases. However the large variability of measured values indicates that plasma Aβ is not a suitable marker of incipient AD.
AB - Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-β-{40} (Aβ-{40}) and Aβ-{42} in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Aβ-{42}, as well as the Aβ-{42}/Aβ-{40} ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Aβ-{42} and, to a lesser extent, Aβ-{40} than the stable cases. However the large variability of measured values indicates that plasma Aβ is not a suitable marker of incipient AD.
KW - Alzheimer's disease
KW - Amyloid-β
KW - Mild cognitive impairment
KW - Plasma
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UR - http://www.scopus.com/inward/citedby.url?scp=70350492757&partnerID=8YFLogxK
U2 - 10.3233/JAD-2009-1144
DO - 10.3233/JAD-2009-1144
M3 - Article
C2 - 19584444
AN - SCOPUS:70350492757
VL - 18
SP - 267
EP - 271
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -