Amyloid imaging with AV45 ( 18F-florbetapir) in a cognitively normal AβPP duplication carrier

Laure Saint-Aubert, Mélanie Planton, Didier Hannequin, Jean François Albucher, Marie Bernadette Delisle, Pierre Payoux, Anne Hitzel, Gérard Viallard, Patrice Péran, Dominique Campion, Annie Laquerrière, Emmanuel J. Barbeau, Michéle Puel, Nicolas Raposo, François Chollet, Jérémie Pariente

Research output: Contribution to journalArticlepeer-review


We report the case of a 62-year-old asymptomatic carrier of AβPP gene duplication. He was investigated by MRI and the amyloid ligand 18F-AV45, and compared to Alzheimer's disease patients (n = 11) and healthy controls (n = 11). The neuropsychological examination was normal. Cortical thickness and AV45 retention were comparable to Alzheimer's disease patients. AβPP duplication was diagnosed because cerebral amyloid angiopathy and Alzheimer's disease pathology were found on the neuropathological examination of his youngest brother, who died at 42 from intracerebral hemorrhage. This is the first description of a pre-symptomatic AβPP duplication carrier over 60, despite widespread cerebral amyloid angiopathy, "Alzheimer's like" atrophy, and amyloid deposition.

Original languageEnglish
Pages (from-to)877-883
Number of pages7
JournalJournal of Alzheimer's Disease
Issue number4
Publication statusPublished - 2012


  • AβPP duplication
  • Alzheimer's disease
  • amyloid
  • AV45 PET
  • cerebral amyloid angiopathy
  • genetics
  • MRI

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


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