Amyloid neuropathy simulating lower motor neuron disease

Angelo Quattrini, R. Nemni, B. Sferrazza, G. Ricevuti, G. Dell'Antonio, A. Lazzerini, S. Iannaccone

Research output: Contribution to journalArticlepeer-review


We report a 57-year-old man with progressive symmetric weakness and fasciculation affecting the legs. Electromyography revealed fibrillations and neurogenic motor unit potentials in the leg muscles. Biopsy of a motor branch of the obturator nerve revealed axonal degeneration, loss of myelinated nerve fibers, and amyloidosis with deposits of lambda light chains. At 6-month follow-up, the patient manifested sensory and autonomic symptoms, and lambda light chains were first detected in the serum. In this case, diagnosis of amyloidosis remained elusive until motor nerve biopsy.

Original languageEnglish
Pages (from-to)600-602
Number of pages3
Issue number2
Publication statusPublished - Aug 1998

ASJC Scopus subject areas

  • Neuroscience(all)


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