L'AMILOIDOSI DELLE ISOLE DEL LANGERHANS ED I SUOI RIFLESSI NEI RIGUARDI DELLA COMPONENTE CELLULARE DELLE STESSE

Translated title of the contribution: Amyloidosis in the islets of Langerhans and its effects on their cellular population

M. Melato, G. Antonutto, L. Giarelli, M. Mlac

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was made on 22 cases of amyloidosis of the islets of Langerhans of the pancreas. First of all a preliminary retrospective clinical examination was made to ascertain whether diabetes was present, and, if so, how long it had lasted. In this way two groups were obtained, both having amyloidosis of the islets of Langerhans; one made up of 16 diabetic subjects; the other of 6 non diabetic subjects. In the second group the average age was higher than in the first group (69/83). With these premises a thorough study was made of the cytology of the islets affected by amyloid infiltration, the conclusions being as follows: amyloid affection of the Langerhans islets, though being in some way connected with diabetes and the general process of aging, appears so far not to have its aetiopathogenesis elucidated; the percentage of islets with amyloid deposits varies from one case to another. In the present patient material it was also observed that there was on average a higher percentage of amyloidotic islets in diabetic than in nondiabetic patients. On comparison of the means, by calculation of the partial and of the simple correlations in the islet populations studied, it seems to be that the diabetes is systematically correlated with a percentage diminution of the beta cells and an increase of the alpha cells. The amyloid would seem to have at the most a 'homogenizing' effect.

Translated title of the contributionAmyloidosis in the islets of Langerhans and its effects on their cellular population
Original languageItalian
Pages (from-to)109-118
Number of pages10
JournalPathologica
Volume67
Issue number965-966
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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