TY - JOUR
T1 - Amyotrophic lateral sclerosis and environmental factors
AU - Bozzoni, Virginia
AU - Pansarasa, Orietta
AU - Diamanti, Luca
AU - Nosari, Guido
AU - Cereda, Cristina
AU - Ceroni, Mauro
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that affects central and peripheral motor neuron cells. Its etiology is unknown, although a relationship between genetic background and environmental factors may play a major role in triggering the neurodegeneration. In this review, we analyze the role of environmental factors in ALS: heavy metals, electromagnetic fields and electric shocks, pesticides, β-N-methylamino-L-alanine, physical activity and the controversial role of sports. The literature on the single issues is analyzed in an attempt to clarify, as clearly as possible, whether each risk factor significantly contributes to the disease pathogenesis. After summarizing conflicting observations and data, the authors provide a final synthetic statement.
AB - Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that affects central and peripheral motor neuron cells. Its etiology is unknown, although a relationship between genetic background and environmental factors may play a major role in triggering the neurodegeneration. In this review, we analyze the role of environmental factors in ALS: heavy metals, electromagnetic fields and electric shocks, pesticides, β-N-methylamino-L-alanine, physical activity and the controversial role of sports. The literature on the single issues is analyzed in an attempt to clarify, as clearly as possible, whether each risk factor significantly contributes to the disease pathogenesis. After summarizing conflicting observations and data, the authors provide a final synthetic statement.
KW - ALS
KW - BMAA
KW - Electromagnetic fields
KW - Metals
KW - Pesticides
KW - Sports
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U2 - 10.11138/FNeur/2016.31.1.007
DO - 10.11138/FNeur/2016.31.1.007
M3 - Article
AN - SCOPUS:84962129160
VL - 31
SP - 7
EP - 19
JO - Functional Neurology
JF - Functional Neurology
SN - 0393-5264
IS - 1
ER -