TY - JOUR
T1 - Amyotrophic lateral sclerosis and food intake
AU - For Slalom
AU - Parals
AU - and for Slap Groups
AU - Pupillo, Elisabetta
AU - Bianchi, Elisa
AU - Chiò, Adriano
AU - Casale, Federico
AU - Zecca, Chiara
AU - Tortelli, Rosanna
AU - Beghi, Ettore
PY - 2018/4/3
Y1 - 2018/4/3
N2 - Objective: To verify if specific foods and nutrients could be risk factors or protective factors for amyotrophic lateral sclerosis (ALS). Methods: Patients with newly diagnosed ALS from three Italian administrative regions were included. For each patient, a healthy control, matched for age (±5 years), sex and administrative region of residence, was selected by a general practitioner. Cases and controls were interviewed by a trained investigator who filled a validated and reproducible food-frequency questionnaire. Daily intake of macronutrients, micronutrients, fatty acids, and total energy were estimated using an Italian food composition database. Results: Two hundred and twelve cases and 212 controls were included. A risk reduction was found for coffee and tea (odds ratios (OR) = 0.29, 95% CI 0.14–0.60), whole bread (OR = 0.55, 95% CI 0.31–0.99), raw vegetables (OR = 0.25, 95% CI 0.13–0.52) and citrus fruits (OR = 0.49, 95% CI 0.25–0.97). A risk increase was observed for red meat (OR = 2.96, 95% CI 1.46–5.99) and pork and processed meat (OR = 3.87, 95% CI 1.86–8.07). An increased risk was found for total protein (OR = 2.96, 95% CI 1.08–8.10), animal protein (OR = 2.91, 95% CI 1.33–6.38), sodium (OR = 3.96, 95% CI 1.45–10.84), zinc (OR = 2.78, 95% CI 1.01–7.83) and glutamic acid (OR = 3.63, 95% CI 1.08–12.2). Conclusions: Some foods/nutrients may be risk factors and others protective factors for ALS.
AB - Objective: To verify if specific foods and nutrients could be risk factors or protective factors for amyotrophic lateral sclerosis (ALS). Methods: Patients with newly diagnosed ALS from three Italian administrative regions were included. For each patient, a healthy control, matched for age (±5 years), sex and administrative region of residence, was selected by a general practitioner. Cases and controls were interviewed by a trained investigator who filled a validated and reproducible food-frequency questionnaire. Daily intake of macronutrients, micronutrients, fatty acids, and total energy were estimated using an Italian food composition database. Results: Two hundred and twelve cases and 212 controls were included. A risk reduction was found for coffee and tea (odds ratios (OR) = 0.29, 95% CI 0.14–0.60), whole bread (OR = 0.55, 95% CI 0.31–0.99), raw vegetables (OR = 0.25, 95% CI 0.13–0.52) and citrus fruits (OR = 0.49, 95% CI 0.25–0.97). A risk increase was observed for red meat (OR = 2.96, 95% CI 1.46–5.99) and pork and processed meat (OR = 3.87, 95% CI 1.86–8.07). An increased risk was found for total protein (OR = 2.96, 95% CI 1.08–8.10), animal protein (OR = 2.91, 95% CI 1.33–6.38), sodium (OR = 3.96, 95% CI 1.45–10.84), zinc (OR = 2.78, 95% CI 1.01–7.83) and glutamic acid (OR = 3.63, 95% CI 1.08–12.2). Conclusions: Some foods/nutrients may be risk factors and others protective factors for ALS.
KW - Amyotrophic lateral sclerosis
KW - case-control
KW - Italy
KW - nutrition
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U2 - 10.1080/21678421.2017.1418002
DO - 10.1080/21678421.2017.1418002
M3 - Article
C2 - 29268633
AN - SCOPUS:85038634261
VL - 19
SP - 267
EP - 274
JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
SN - 2167-8421
IS - 3-4
ER -