Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD)

S. Zago, B. Poletti, C. Morelli, A. Doretti, V. Silani

Research output: Contribution to journalArticlepeer-review


There is increasing clinical, imaging and neurophatological evidence that Amyotrophic lateral sclerosis (ALS) represents a multisystem neurodegenerative disease. Neurodegeneration is not restricted to motor neurons, but also includes parts of the brain other than the motor cortex, especially the prefrontal and/or anterior temporal lobe, that contribute to the clinical syndrome. In some cases an evident dementia that resembles frontotemporal degeneration (FTD) was observed. It is now suggested that ALS and FTD are closely related conditions with overlapping clinical, pathological, radiological, and genetic characteristics. The presence of a frontal dementia in ALS has also crucial practical consequences for management of the patients, whose disorder requires critical life decisions for enteral nutrition and respiratory complications. It is our intent to provide a brief overview of the relationships between ALS and FTD.

Original languageEnglish
Pages (from-to)39-56
Number of pages18
JournalArchives Italiennes de Biologie
Issue number1
Publication statusPublished - 2011


  • ALS
  • ALS-FTD syndrome
  • FTD

ASJC Scopus subject areas

  • Medicine(all)
  • Cell Biology
  • Physiology


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