An a priori prediction model of response to peginterferon plus ribavirin dual therapy in naïve patients with genotype 1 chronic hepatitis C

Angelo Andriulli, Alessandra Nardi, Vito Di Marco, Antonio Massimo Ippolito, Caius Gavrila, Alessio Aghemo, Daniele Di Paolo, Giovanni Squadrito, Eleonora Grassi, Vincenza Calvaruso, Maria Rosa Valvano, Giuseppina Brancaccio, Antonio Craxi, Mario Angelico, Giovanni Raimondo, Michele Milella, Filomena Morisco, Giovanna Fattovich, Martina Felder, Antonina SmedileMassimo Fasano, Teresa Santantonio, Pietro Gatti, [No Value] NicolaAndriulli, Paolo Tundo, Michele Barone, Raffaele Cozzolongo, D'Andrea Giovanna D'Andrea, Giuseppe Mazzella

Research output: Contribution to journalArticle

Abstract

Background: Aim was to select naïve patients with genotype 1 chronic hepatitis C having a high probability of response to Peg-interferon. +. ribavirin therapy. Methods: In 1073 patients (derivation cohort), predictors of rapid and sustained virological response were identified by logistic analysis; regression coefficients were used to generate prediction models for sustained virological response. Probabilities at baseline and treatment week 4 were utilized to develop a decision rule to select patients with high likelihood of response. The model was then validated in 423 patients (validation cohort). Results: In the derivation cohort, 257 achieved rapid virological response and 818 did not, with sustained virological response rates of 80.2% and 25.4%, respectively; interleukin-28B polymorphisms, fibrosis staging, gamma-glutamyl transferase, and viral load predicted sustained virological response. Assuming a

Original languageEnglish
Pages (from-to)818-825
Number of pages8
JournalDigestive and Liver Disease
Volume46
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • Chronic hepatitis
  • HCV infection
  • Peg-interferon and ribavirin treatment
  • Predictors of sustained virological response, rapid virological response

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

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    Andriulli, A., Nardi, A., Di Marco, V., Ippolito, A. M., Gavrila, C., Aghemo, A., Di Paolo, D., Squadrito, G., Grassi, E., Calvaruso, V., Valvano, M. R., Brancaccio, G., Craxi, A., Angelico, M., Raimondo, G., Milella, M., Morisco, F., Fattovich, G., Felder, M., ... Mazzella, G. (2014). An a priori prediction model of response to peginterferon plus ribavirin dual therapy in naïve patients with genotype 1 chronic hepatitis C. Digestive and Liver Disease, 46(9), 818-825. https://doi.org/10.1016/j.dld.2014.05.015