An accurate method to quantify breathing-induced prostate motion for patients implanted with electromagnetic transponders

Tommaso Giandini, Costanza M.V. Panaino, Barbara Avuzzi, Sara Morlino, Sergio Villa, Nice Bedini, Gabriele Carabelli, Sarah C. Frasca, Anna Romanyukha, Anatoly Rosenfeld, Emanuele Pignoli, Riccardo Valdagni, Mauro Carrara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To validate and apply a method for the quantification of breathing-induced prostate motion (BIPM) for patients treated with radiotherapy and implanted with electromagnetic transponders for prostate localization and tracking. Methods: For the analysis of electromagnetic transponder signal, dedicated software was developed and validated with a programmable breathing simulator phantom. The software was then applied to 1,132 radiotherapy fractions of 30 patients treated in supine position, and to a further 61 fractions of 2 patients treated in prone position. Results: Application of the software in phantom demonstrated reliability of the developed method in determining simulated breathing frequencies and amplitudes. For supine patients, the in vivo analysis of BIPM resulted in median (maximum) amplitudes of 0.10 mm (0.35 mm), 0.24 mm (0.66 mm), and 0.17 mm (0.61 mm) in the left-right (LR), cranio-caudal (CC), and anterior-posterior (AP) directions, respectively. Breathing frequency ranged between 7.73 and 29.43 breaths per minute. For prone patients, the ranges of the BIPM amplitudes were 0.1-0.5 mm, 0.5-1.3 mm, and 0.7-1.7 mm in the LR, CC, and AP directions, respectively. Conclusions: The developed method was able to detect the BIPM with sub-millimeter accuracy. While for patients treated in supine position the BIPM represents a reduced source of treatment uncertainty, for patients treated in prone position, it can be higher than 3 mm.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalTumori
Volume103
Issue number2
DOIs
Publication statusPublished - Mar 1 2017

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Electromagnetic Phenomena
Prostate
Respiration
Prone Position
Software
Supine Position
Radiotherapy
Uncertainty

Keywords

  • Electromagnetic tracking
  • Intrafraction motion
  • Prostate radiotherapy

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

An accurate method to quantify breathing-induced prostate motion for patients implanted with electromagnetic transponders. / Giandini, Tommaso; Panaino, Costanza M.V.; Avuzzi, Barbara; Morlino, Sara; Villa, Sergio; Bedini, Nice; Carabelli, Gabriele; Frasca, Sarah C.; Romanyukha, Anna; Rosenfeld, Anatoly; Pignoli, Emanuele; Valdagni, Riccardo; Carrara, Mauro.

In: Tumori, Vol. 103, No. 2, 01.03.2017, p. 136-142.

Research output: Contribution to journalArticle

Giandini, Tommaso ; Panaino, Costanza M.V. ; Avuzzi, Barbara ; Morlino, Sara ; Villa, Sergio ; Bedini, Nice ; Carabelli, Gabriele ; Frasca, Sarah C. ; Romanyukha, Anna ; Rosenfeld, Anatoly ; Pignoli, Emanuele ; Valdagni, Riccardo ; Carrara, Mauro. / An accurate method to quantify breathing-induced prostate motion for patients implanted with electromagnetic transponders. In: Tumori. 2017 ; Vol. 103, No. 2. pp. 136-142.
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AU - Morlino, Sara

AU - Villa, Sergio

AU - Bedini, Nice

AU - Carabelli, Gabriele

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AB - Purpose: To validate and apply a method for the quantification of breathing-induced prostate motion (BIPM) for patients treated with radiotherapy and implanted with electromagnetic transponders for prostate localization and tracking. Methods: For the analysis of electromagnetic transponder signal, dedicated software was developed and validated with a programmable breathing simulator phantom. The software was then applied to 1,132 radiotherapy fractions of 30 patients treated in supine position, and to a further 61 fractions of 2 patients treated in prone position. Results: Application of the software in phantom demonstrated reliability of the developed method in determining simulated breathing frequencies and amplitudes. For supine patients, the in vivo analysis of BIPM resulted in median (maximum) amplitudes of 0.10 mm (0.35 mm), 0.24 mm (0.66 mm), and 0.17 mm (0.61 mm) in the left-right (LR), cranio-caudal (CC), and anterior-posterior (AP) directions, respectively. Breathing frequency ranged between 7.73 and 29.43 breaths per minute. For prone patients, the ranges of the BIPM amplitudes were 0.1-0.5 mm, 0.5-1.3 mm, and 0.7-1.7 mm in the LR, CC, and AP directions, respectively. Conclusions: The developed method was able to detect the BIPM with sub-millimeter accuracy. While for patients treated in supine position the BIPM represents a reduced source of treatment uncertainty, for patients treated in prone position, it can be higher than 3 mm.

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