Abstract
Background: To investigate the role of Kodama PenA subtype in influencing survival in patients with early gastric cancer (EGC). Methods: All patients surgically treated for EGC at 7 Italian centers (Forlì Varese, Siena, Verona, Milan, Rome and Perugia) belonging to the Italian Research Group for Gastric Cancer (GIRCG) from January 1982 and December 2009 were included. Results: PenA patients were 230 (21.5%) while other types were 839 (78.5%). Nodal metastases were more common in PenA (30.7%) than non-PenA (10.4%) EGCs. Among preoperative variables, only age (OR 1.02; 95% CI 1.00–1.03, p = 0.009) and macrotype III (OR 1.95; 95% CI 1.39–2.75, p = 0.0001) were significantly associated with Pen A type. Survival analysis performed on N0 patients demonstrated that only size >2 cm (HR 1.85; 95% CI 1.12–3.05, p = 0.017) and age (HR 1.06; 95% CI 1.03–1.08, p < 0.0001) were independent poor prognostic factor. Among N+ patients age (HR 1.04; 95% CI 1.00–1.07, p = 0.048), number of positive lymph nodes (HR 1.13; 95% CI 1.05–1.20, p = 0.0002) and PenA (HR 4.23; 95% CI 1.70–10.55, p = 0.002) were significantly correlated with poor prognosis at multivariate analysis. Conclusions: Kodama PenA subtype was the most powerful independent prognostic factor in patients with nodal metastases. Its status should always be investigated in EGCs patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1186-1190 |
| Number of pages | 5 |
| Journal | European Journal of Surgical Oncology |
| Volume | 44 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2018 |
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Keywords
- Early gastric cancer
- Histotype
- Lymph node metastases
- Prognosis
- Prognostic factors
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
An aggressive early gastric cancer : Kodama's PenA type. / GIRCG.
In: European Journal of Surgical Oncology, Vol. 44, No. 8, 01.08.2018, p. 1186-1190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An aggressive early gastric cancer
T2 - Kodama's PenA type
AU - GIRCG
AU - Morgagni, Paolo
AU - Solaini, Leonardo
AU - Saragoni, Luca
AU - Bencivenga, Maria
AU - Graziosi, Luigina
AU - Marino, Elisabetta
AU - Marrelli, Daniele
AU - Rausei, Stefano
AU - Rosa, Fausto
AU - Scarpi, Emanuela
AU - Tomezzoli, Anna
AU - Tringali, Domenico
AU - Vindigni, Carla
AU - Vittimberga, Giovanni
AU - Roviello, Franco
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Background: To investigate the role of Kodama PenA subtype in influencing survival in patients with early gastric cancer (EGC). Methods: All patients surgically treated for EGC at 7 Italian centers (Forlì Varese, Siena, Verona, Milan, Rome and Perugia) belonging to the Italian Research Group for Gastric Cancer (GIRCG) from January 1982 and December 2009 were included. Results: PenA patients were 230 (21.5%) while other types were 839 (78.5%). Nodal metastases were more common in PenA (30.7%) than non-PenA (10.4%) EGCs. Among preoperative variables, only age (OR 1.02; 95% CI 1.00–1.03, p = 0.009) and macrotype III (OR 1.95; 95% CI 1.39–2.75, p = 0.0001) were significantly associated with Pen A type. Survival analysis performed on N0 patients demonstrated that only size >2 cm (HR 1.85; 95% CI 1.12–3.05, p = 0.017) and age (HR 1.06; 95% CI 1.03–1.08, p < 0.0001) were independent poor prognostic factor. Among N+ patients age (HR 1.04; 95% CI 1.00–1.07, p = 0.048), number of positive lymph nodes (HR 1.13; 95% CI 1.05–1.20, p = 0.0002) and PenA (HR 4.23; 95% CI 1.70–10.55, p = 0.002) were significantly correlated with poor prognosis at multivariate analysis. Conclusions: Kodama PenA subtype was the most powerful independent prognostic factor in patients with nodal metastases. Its status should always be investigated in EGCs patients.
AB - Background: To investigate the role of Kodama PenA subtype in influencing survival in patients with early gastric cancer (EGC). Methods: All patients surgically treated for EGC at 7 Italian centers (Forlì Varese, Siena, Verona, Milan, Rome and Perugia) belonging to the Italian Research Group for Gastric Cancer (GIRCG) from January 1982 and December 2009 were included. Results: PenA patients were 230 (21.5%) while other types were 839 (78.5%). Nodal metastases were more common in PenA (30.7%) than non-PenA (10.4%) EGCs. Among preoperative variables, only age (OR 1.02; 95% CI 1.00–1.03, p = 0.009) and macrotype III (OR 1.95; 95% CI 1.39–2.75, p = 0.0001) were significantly associated with Pen A type. Survival analysis performed on N0 patients demonstrated that only size >2 cm (HR 1.85; 95% CI 1.12–3.05, p = 0.017) and age (HR 1.06; 95% CI 1.03–1.08, p < 0.0001) were independent poor prognostic factor. Among N+ patients age (HR 1.04; 95% CI 1.00–1.07, p = 0.048), number of positive lymph nodes (HR 1.13; 95% CI 1.05–1.20, p = 0.0002) and PenA (HR 4.23; 95% CI 1.70–10.55, p = 0.002) were significantly correlated with poor prognosis at multivariate analysis. Conclusions: Kodama PenA subtype was the most powerful independent prognostic factor in patients with nodal metastases. Its status should always be investigated in EGCs patients.
KW - Early gastric cancer
KW - Histotype
KW - Lymph node metastases
KW - Prognosis
KW - Prognostic factors
UR - http://www.scopus.com/inward/record.url?scp=85049981556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049981556&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2018.03.016
DO - 10.1016/j.ejso.2018.03.016
M3 - Article
C2 - 29628438
AN - SCOPUS:85049981556
VL - 44
SP - 1186
EP - 1190
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 8
ER -