An "all-wheel drive" proposal to accelerate clinical research in common and rare neurological diseases

Marco Salvetti; Mario A Battaglia; Massimiliano Di Filippo; Gian Luigi Mancardi; Michelangelo Mancuso; Francesco Patti; Maria Pia Sormani; Paola Zaratin

doi:10.1007/s10072-019-04189-4

An "all-wheel drive" proposal to accelerate clinical research in common and rare neurological diseases

Marco Salvetti, Mario A Battaglia, Massimiliano Di Filippo, Gian Luigi Mancardi, Michelangelo Mancuso, Francesco Patti, Maria Pia Sormani, Paola Zaratin

www.neuromed.it

Research output: Contribution to journal › Review article

Abstract

The complex biology of neurological diseases calls for collaborative efforts that may increase the success rate of clinical research. Models have been proposed, but concrete actions remain insufficient. Based on recent considerations from basic science, from science of patient input and from an analysis of scientific resources in Italy, we here explain why our country may represent an appropriate environment for such actions. Furthermore, we sketch operational framework and business model to be applied in order to accelerate, in parallel, the development of therapies in common and rare diseases.

Original language	English
Journal	Neurol. Sci.
DOIs	https://doi.org/10.1007/s10072-019-04189-4
Publication status	E-pub ahead of print - Dec 19 2019

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Salvetti, M., Battaglia, M. A., Di Filippo, M., Mancardi, G. L., Mancuso, M., Patti, F., Sormani, M. P., & Zaratin, P. (2019). An "all-wheel drive" proposal to accelerate clinical research in common and rare neurological diseases. Neurol. Sci.. https://doi.org/10.1007/s10072-019-04189-4

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T1 - An "all-wheel drive" proposal to accelerate clinical research in common and rare neurological diseases

AU - Salvetti, Marco

AU - Battaglia, Mario A

AU - Di Filippo, Massimiliano

AU - Mancardi, Gian Luigi

AU - Mancuso, Michelangelo

AU - Patti, Francesco

AU - Sormani, Maria Pia

AU - Zaratin, Paola

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N2 - The complex biology of neurological diseases calls for collaborative efforts that may increase the success rate of clinical research. Models have been proposed, but concrete actions remain insufficient. Based on recent considerations from basic science, from science of patient input and from an analysis of scientific resources in Italy, we here explain why our country may represent an appropriate environment for such actions. Furthermore, we sketch operational framework and business model to be applied in order to accelerate, in parallel, the development of therapies in common and rare diseases.

AB - The complex biology of neurological diseases calls for collaborative efforts that may increase the success rate of clinical research. Models have been proposed, but concrete actions remain insufficient. Based on recent considerations from basic science, from science of patient input and from an analysis of scientific resources in Italy, we here explain why our country may represent an appropriate environment for such actions. Furthermore, we sketch operational framework and business model to be applied in order to accelerate, in parallel, the development of therapies in common and rare diseases.

U2 - 10.1007/s10072-019-04189-4

DO - 10.1007/s10072-019-04189-4

M3 - Review article

C2 - 31858329

JO - Neurol. Sci.

JF - Neurol. Sci.

SN - 1590-1874

ER -

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10.1007/s10072-019-04189-4

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NEUROMED - DETERMINANTI MOLECOLARI E PARAMETRI NEUROFISIOLOGICI E DI IMAGING CHE INFLUENZANO L'ESPRESSIONE DEL DANNO DEL SNC E GLI EFFETTI DELLA RIABILITAZIONE

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An "all-wheel drive" proposal to accelerate clinical research in common and rare neurological diseases

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NEUROMED - DETERMINANTI MOLECOLARI E PARAMETRI NEUROFISIOLOGICI E DI IMAGING CHE INFLUENZANO L'ESPRESSIONE DEL DANNO DEL SNC E GLI EFFETTI DELLA RIABILITAZIONE