An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

Stefan C. Meuer, Rebecca E. Hussey, Marina Fabbi, David Fox, Oreste Acuto, Kathleen A. Fitzgerald, James C. Hodgdon, Jeffrey P. Protentis, Stuart F. Schlossman, Ellis L. Reinherz

Research output: Contribution to journalArticle

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Abstract

A series of seven monoclonal antibodies was produced against the T-lineage-specific 50 kd T11 sheep erythrocyte rosette (SRBC) receptor protein in order to define the function of the molecule. Three distinct epitopes were detected: T111, the SRBC binding site expressed on all T lymphocytes and thymocytes; T112, an epitope unrelated to the SRBC binding site but with a similar distribution; and T113, a neo-epitope expressed only upon T-cell activation. Simultaneous triggering of T112 and T113 epitopes by monoclonal antibodies induces T lymphocytes to proliferate and mediate their functional programs in the absence of antigen and/or antigen-presenting cells. This antigen-independent mode of triggering is distinct from that involving the T3-Ti antigen receptor complex and represents an alternate pathway of T-cell activation. Given that T11 is the earliest T-lineage surface glycoprotein to appear in thymic ontogeny and is thus expressed before T3-Ti, the former may be involved in clonal expansion and/or differentiation during early development.

Original languageEnglish
Pages (from-to)897-906
Number of pages10
JournalCell
Volume36
Issue number4
DOIs
Publication statusPublished - 1984

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T-cells
Epitopes
Sheep
Erythrocytes
Chemical activation
T-Lymphocytes
Proteins
Binding Sites
Monoclonal Antibodies
CD3 Antigens
Antigens
Antigen Receptors
Membrane Glycoproteins
Antigen-Presenting Cells
Thymocytes
Molecules

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Meuer, S. C., Hussey, R. E., Fabbi, M., Fox, D., Acuto, O., Fitzgerald, K. A., ... Reinherz, E. L. (1984). An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell, 36(4), 897-906. https://doi.org/10.1016/0092-8674(84)90039-4

An alternative pathway of T-cell activation : A functional role for the 50 kd T11 sheep erythrocyte receptor protein. / Meuer, Stefan C.; Hussey, Rebecca E.; Fabbi, Marina; Fox, David; Acuto, Oreste; Fitzgerald, Kathleen A.; Hodgdon, James C.; Protentis, Jeffrey P.; Schlossman, Stuart F.; Reinherz, Ellis L.

In: Cell, Vol. 36, No. 4, 1984, p. 897-906.

Research output: Contribution to journalArticle

Meuer, SC, Hussey, RE, Fabbi, M, Fox, D, Acuto, O, Fitzgerald, KA, Hodgdon, JC, Protentis, JP, Schlossman, SF & Reinherz, EL 1984, 'An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein', Cell, vol. 36, no. 4, pp. 897-906. https://doi.org/10.1016/0092-8674(84)90039-4
Meuer, Stefan C. ; Hussey, Rebecca E. ; Fabbi, Marina ; Fox, David ; Acuto, Oreste ; Fitzgerald, Kathleen A. ; Hodgdon, James C. ; Protentis, Jeffrey P. ; Schlossman, Stuart F. ; Reinherz, Ellis L. / An alternative pathway of T-cell activation : A functional role for the 50 kd T11 sheep erythrocyte receptor protein. In: Cell. 1984 ; Vol. 36, No. 4. pp. 897-906.
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