An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

S. Cascinu; F. Graziano; V. Catalano; M. P. Staccioli; M. C. Rossi; A. M. Baldelli; S. Barni; A. Brenna; S. Secondino; P. Muretto; G. Catalano

doi:10.1038/sj.bjc.6600155

An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

S. Cascinu, F. Graziano, V. Catalano, M. P. Staccioli, M. C. Rossi, A. M. Baldelli, S. Barni, A. Brenna, S. Secondino, P. Muretto, G. Catalano

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Tumours of patients with node-positive rectal cancer were studied by immunohistochemistry for p53, BAX and vascular endothelial growth factor expressions. Results were correlated to the relapse rate, the pattern of relapse and the event-free survival after radical surgery and adjuvant chemoradiation. After a median follow-up of 60 months, 39 patients remained disease-free and 40 patients relapsed (18 local relapses and 22 distant metastases). The majority of disease-free patients showed p53 negative and vascular endothelial growth factor negative tumours. Local relapses occurred more frequently in patients with p53 overexpressing turnouts (P

Original language	English
Pages (from-to)	744-749
Number of pages	6
Journal	British Journal of Cancer
Volume	86
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjc.6600155
Publication status	Published - Mar 4 2002

Keywords

Angiogenesis
Apoptosis
BAX
Chemotherapy
Metastasis
P53
Radiotherapy
Rectal cancer
Vascular endothelial growth factor

ASJC Scopus subject areas

Cancer Research
Oncology

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Cascinu, S., Graziano, F., Catalano, V., Staccioli, M. P., Rossi, M. C., Baldelli, A. M., Barni, S., Brenna, A., Secondino, S., Muretto, P., & Catalano, G. (2002). An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. British Journal of Cancer, 86(5), 744-749. https://doi.org/10.1038/sj.bjc.6600155

An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. / Cascinu, S.; Graziano, F.; Catalano, V.; Staccioli, M. P.; Rossi, M. C.; Baldelli, A. M.; Barni, S.; Brenna, A.; Secondino, S.; Muretto, P.; Catalano, G.

In: British Journal of Cancer, Vol. 86, No. 5, 04.03.2002, p. 744-749.

Research output: Contribution to journal › Article › peer-review

Cascinu, S, Graziano, F, Catalano, V, Staccioli, MP, Rossi, MC, Baldelli, AM, Barni, S, Brenna, A, Secondino, S, Muretto, P & Catalano, G 2002, 'An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation', British Journal of Cancer, vol. 86, no. 5, pp. 744-749. https://doi.org/10.1038/sj.bjc.6600155

Cascinu S, Graziano F, Catalano V, Staccioli MP, Rossi MC, Baldelli AM et al. An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. British Journal of Cancer. 2002 Mar 4;86(5):744-749. https://doi.org/10.1038/sj.bjc.6600155

Cascinu, S. ; Graziano, F. ; Catalano, V. ; Staccioli, M. P. ; Rossi, M. C. ; Baldelli, A. M. ; Barni, S. ; Brenna, A. ; Secondino, S. ; Muretto, P. ; Catalano, G. / An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. In: British Journal of Cancer. 2002 ; Vol. 86, No. 5. pp. 744-749.

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AU - Staccioli, M. P.

AU - Rossi, M. C.

AU - Baldelli, A. M.

AU - Barni, S.

AU - Brenna, A.

AU - Secondino, S.

AU - Muretto, P.

AU - Catalano, G.

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An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

Abstract

Keywords

ASJC Scopus subject areas

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