An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

S. Cascinu, F. Graziano, V. Catalano, M. P. Staccioli, M. C. Rossi, A. M. Baldelli, S. Barni, A. Brenna, S. Secondino, P. Muretto, G. Catalano

Research output: Contribution to journalArticlepeer-review

Abstract

Tumours of patients with node-positive rectal cancer were studied by immunohistochemistry for p53, BAX and vascular endothelial growth factor expressions. Results were correlated to the relapse rate, the pattern of relapse and the event-free survival after radical surgery and adjuvant chemoradiation. After a median follow-up of 60 months, 39 patients remained disease-free and 40 patients relapsed (18 local relapses and 22 distant metastases). The majority of disease-free patients showed p53 negative and vascular endothelial growth factor negative tumours. Local relapses occurred more frequently in patients with p53 overexpressing turnouts (P

Original languageEnglish
Pages (from-to)744-749
Number of pages6
JournalBritish Journal of Cancer
Volume86
Issue number5
DOIs
Publication statusPublished - Mar 4 2002

Keywords

  • Angiogenesis
  • Apoptosis
  • BAX
  • Chemotherapy
  • Metastasis
  • P53
  • Radiotherapy
  • Rectal cancer
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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