An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

S. Cascinu; F. Graziano; V. Catalano; M. P. Staccioli; M. C. Rossi; A. M. Baldelli; S. Barni; A. Brenna; S. Secondino; P. Muretto; G. Catalano

doi:10.1038/sj.bjc.6600155

An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

S. Cascinu, F. Graziano, V. Catalano, M. P. Staccioli, M. C. Rossi, A. M. Baldelli, S. Barni, A. Brenna, S. Secondino, P. Muretto, G. Catalano

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Tumours of patients with node-positive rectal cancer were studied by immunohistochemistry for p53, BAX and vascular endothelial growth factor expressions. Results were correlated to the relapse rate, the pattern of relapse and the event-free survival after radical surgery and adjuvant chemoradiation. After a median follow-up of 60 months, 39 patients remained disease-free and 40 patients relapsed (18 local relapses and 22 distant metastases). The majority of disease-free patients showed p53 negative and vascular endothelial growth factor negative tumours. Local relapses occurred more frequently in patients with p53 overexpressing turnouts (P

Original language	English
Pages (from-to)	744-749
Number of pages	6
Journal	British Journal of Cancer
Volume	86
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjc.6600155
Publication status	Published - Mar 4 2002

Keywords

Angiogenesis
Apoptosis
BAX
Chemotherapy
Metastasis
P53
Radiotherapy
Rectal cancer
Vascular endothelial growth factor

ASJC Scopus subject areas

Cancer Research
Oncology

Access to Document

10.1038/sj.bjc.6600155

Fingerprint

Dive into the research topics of 'An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation'. Together they form a unique fingerprint.

Cite this

Cascinu, S., Graziano, F., Catalano, V., Staccioli, M. P., Rossi, M. C., Baldelli, A. M., Barni, S., Brenna, A., Secondino, S., Muretto, P., & Catalano, G. (2002). An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. British Journal of Cancer, 86(5), 744-749. https://doi.org/10.1038/sj.bjc.6600155

An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. / Cascinu, S.; Graziano, F.; Catalano, V. et al.

In: British Journal of Cancer, Vol. 86, No. 5, 04.03.2002, p. 744-749.

Research output: Contribution to journal › Article › peer-review

Cascinu, S, Graziano, F, Catalano, V, Staccioli, MP, Rossi, MC, Baldelli, AM, Barni, S, Brenna, A, Secondino, S, Muretto, P & Catalano, G 2002, 'An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation', British Journal of Cancer, vol. 86, no. 5, pp. 744-749. https://doi.org/10.1038/sj.bjc.6600155

Cascinu S, Graziano F, Catalano V, Staccioli MP, Rossi MC, Baldelli AM et al. An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. British Journal of Cancer. 2002 Mar 4;86(5):744-749. doi: 10.1038/sj.bjc.6600155

@article{1f0ee323392c467c8b5c1c1e6af16739,

title = "An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation",

abstract = "Tumours of patients with node-positive rectal cancer were studied by immunohistochemistry for p53, BAX and vascular endothelial growth factor expressions. Results were correlated to the relapse rate, the pattern of relapse and the event-free survival after radical surgery and adjuvant chemoradiation. After a median follow-up of 60 months, 39 patients remained disease-free and 40 patients relapsed (18 local relapses and 22 distant metastases). The majority of disease-free patients showed p53 negative and vascular endothelial growth factor negative tumours. Local relapses occurred more frequently in patients with p53 overexpressing turnouts (P",

keywords = "Angiogenesis, Apoptosis, BAX, Chemotherapy, Metastasis, P53, Radiotherapy, Rectal cancer, Vascular endothelial growth factor",

author = "S. Cascinu and F. Graziano and V. Catalano and Staccioli, {M. P.} and Rossi, {M. C.} and Baldelli, {A. M.} and S. Barni and A. Brenna and S. Secondino and P. Muretto and G. Catalano",

year = "2002",

month = mar,

day = "4",

doi = "10.1038/sj.bjc.6600155",

language = "English",

volume = "86",

pages = "744--749",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

AU - Cascinu, S.

AU - Graziano, F.

AU - Catalano, V.

AU - Staccioli, M. P.

AU - Rossi, M. C.

AU - Baldelli, A. M.

AU - Barni, S.

AU - Brenna, A.

AU - Secondino, S.

AU - Muretto, P.

AU - Catalano, G.

PY - 2002/3/4

Y1 - 2002/3/4

N2 - Tumours of patients with node-positive rectal cancer were studied by immunohistochemistry for p53, BAX and vascular endothelial growth factor expressions. Results were correlated to the relapse rate, the pattern of relapse and the event-free survival after radical surgery and adjuvant chemoradiation. After a median follow-up of 60 months, 39 patients remained disease-free and 40 patients relapsed (18 local relapses and 22 distant metastases). The majority of disease-free patients showed p53 negative and vascular endothelial growth factor negative tumours. Local relapses occurred more frequently in patients with p53 overexpressing turnouts (P

AB - Tumours of patients with node-positive rectal cancer were studied by immunohistochemistry for p53, BAX and vascular endothelial growth factor expressions. Results were correlated to the relapse rate, the pattern of relapse and the event-free survival after radical surgery and adjuvant chemoradiation. After a median follow-up of 60 months, 39 patients remained disease-free and 40 patients relapsed (18 local relapses and 22 distant metastases). The majority of disease-free patients showed p53 negative and vascular endothelial growth factor negative tumours. Local relapses occurred more frequently in patients with p53 overexpressing turnouts (P

KW - Angiogenesis

KW - Apoptosis

KW - BAX

KW - Chemotherapy

KW - Metastasis

KW - P53

KW - Radiotherapy

KW - Rectal cancer

KW - Vascular endothelial growth factor

UR - http://www.scopus.com/inward/record.url?scp=18344388638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344388638&partnerID=8YFLogxK

U2 - 10.1038/sj.bjc.6600155

DO - 10.1038/sj.bjc.6600155

M3 - Article

C2 - 11875737

AN - SCOPUS:18344388638

VL - 86

SP - 744

EP - 749

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 5

ER -

An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this