Abstract
Tumours of patients with node-positive rectal cancer were studied by immunohistochemistry for p53, BAX and vascular endothelial growth factor expressions. Results were correlated to the relapse rate, the pattern of relapse and the event-free survival after radical surgery and adjuvant chemoradiation. After a median follow-up of 60 months, 39 patients remained disease-free and 40 patients relapsed (18 local relapses and 22 distant metastases). The majority of disease-free patients showed p53 negative and vascular endothelial growth factor negative tumours. Local relapses occurred more frequently in patients with p53 overexpressing turnouts (P
Original language | English |
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Pages (from-to) | 744-749 |
Number of pages | 6 |
Journal | British Journal of Cancer |
Volume | 86 |
Issue number | 5 |
DOIs | |
Publication status | Published - Mar 4 2002 |
Keywords
- Angiogenesis
- Apoptosis
- BAX
- Chemotherapy
- Metastasis
- P53
- Radiotherapy
- Rectal cancer
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Cancer Research
- Oncology