An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Laura Senovilla, Ilio Vitale, Isabelle Martins, Oliver Kepp, Lorenzo Galluzzi, Laurence Zitvoge, Maria Castedo, Guido Kroemer

Research output: Contribution to journalArticlepeer-review

Abstract

One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

Original languageEnglish
Article numbere22409
JournalOncoImmunology
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Breast carcinoma
  • Calreticulin
  • HMGB1
  • Hyperploidy
  • Immunogenic cell death
  • Mitotic catastrophe

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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