An approach using lecithin treatment for olivopontocerebellar atrophies

G. Finocchiaro, S. Di Donato, M. Madonna, R. Fusi, H. Ladinsky, S. Consolo

Research output: Contribution to journalArticle

Abstract

A therapeutic trial with two different lecithins, with 32 and 7% phosphatidylcholine respectively, was performed for 3 months on 11 patients with clinical diagnosis of dominant, recessive and sporadic olivopontocerebellar atrophies. The correlation between plasma choline levels and the clinical picture shows a clinical worsening with very high choline levels and a slight improvement with smaller increases of plasma choline levels. The possible role in these disorders of phosphatidylcholine and linoleic acid - both present in lecithin - is discussed, with relationship to these findings.

Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalEuropean Neurology
Volume24
Issue number6
DOIs
Publication statusPublished - 1985

Keywords

  • Choline
  • Lecithin
  • Olivopontocerebellar atrophy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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