An assessment of transmission disequilibrium between quantitative measures of childhood problem behaviors and DRD2/Taql and DRD4/48bp-repeat polymorphisms

Cecilia Marino, Laura Vanzin, Roberto Giorda, Alessandra Frigerio, Maria Luisa Lorusso, Maria Nobile, Massimo Molteni, Marco Battaglia

Research output: Contribution to journalArticle

Abstract

In a pilot study of 120 children with reading disabilities, we assessed the presence of linkage and association between the DRD2/Taql and the DRD4/48bp-repeat polymorphisms and quantitative measures of behavioral problems derived from parental rated Child Behavior Checklist (CBCL) [Achenbach, T. M. (1991). TM Manual for the CBCL 14-18. Burlington, VT: University of Vermont]. Analyses included measures of between-family association, and a test of the presence of linkage and association by a logistic regression-based extension of the Transmission Disequilibrium Test (i.e., the logistic regression quantitative TDT). In between-family association analyses the "Social Problem" scale was weakly associated with the number of risk alleles of DRD2 and DRD4, while the "Withdrawn" scale was related to the number of risk alleles of DRD4 (the 7-repeat and the A1 allele respectively were considered the risk alleles). Logistic regression quantitative TDTs yielded statistically significant evidence in favor of linkage and association between DRD2 and "Social Problems" (Wald χ 2 = 4.13, df = 1, p = 0.042, Odds Ratio = 1.97). A statistical trend in favor of linkage and association was found for "Withdrawn" and DRD4 (Wald χ 2 = 2.65, df = 1, p = 0.104, Odds Ratio =1.44). Although preliminary, these findings are consistent with previous data that suggest a role of the same polymorphism in influencing individual sensitivity to reward and response to social cues and reinforcements in man and animal.

Original languageEnglish
Pages (from-to)495-502
Number of pages8
JournalBehavior Genetics
Volume34
Issue number5
DOIs
Publication statusPublished - Sep 2004

Fingerprint

behavior problems
childhood
disequilibrium
linkage (genetics)
allele
polymorphism
Alleles
genetic polymorphism
social problems
alleles
logistics
social problem
Logistic Models
Social Problems
Child Behavior
Checklist
odds ratio
Odds Ratio
Disabled Children
disability

Keywords

  • CBCL
  • DRD2
  • DRD4
  • quantitative transmission disequilibrium test

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

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title = "An assessment of transmission disequilibrium between quantitative measures of childhood problem behaviors and DRD2/Taql and DRD4/48bp-repeat polymorphisms",
abstract = "In a pilot study of 120 children with reading disabilities, we assessed the presence of linkage and association between the DRD2/Taql and the DRD4/48bp-repeat polymorphisms and quantitative measures of behavioral problems derived from parental rated Child Behavior Checklist (CBCL) [Achenbach, T. M. (1991). TM Manual for the CBCL 14-18. Burlington, VT: University of Vermont]. Analyses included measures of between-family association, and a test of the presence of linkage and association by a logistic regression-based extension of the Transmission Disequilibrium Test (i.e., the logistic regression quantitative TDT). In between-family association analyses the {"}Social Problem{"} scale was weakly associated with the number of risk alleles of DRD2 and DRD4, while the {"}Withdrawn{"} scale was related to the number of risk alleles of DRD4 (the 7-repeat and the A1 allele respectively were considered the risk alleles). Logistic regression quantitative TDTs yielded statistically significant evidence in favor of linkage and association between DRD2 and {"}Social Problems{"} (Wald χ 2 = 4.13, df = 1, p = 0.042, Odds Ratio = 1.97). A statistical trend in favor of linkage and association was found for {"}Withdrawn{"} and DRD4 (Wald χ 2 = 2.65, df = 1, p = 0.104, Odds Ratio =1.44). Although preliminary, these findings are consistent with previous data that suggest a role of the same polymorphism in influencing individual sensitivity to reward and response to social cues and reinforcements in man and animal.",
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T1 - An assessment of transmission disequilibrium between quantitative measures of childhood problem behaviors and DRD2/Taql and DRD4/48bp-repeat polymorphisms

AU - Marino, Cecilia

AU - Vanzin, Laura

AU - Giorda, Roberto

AU - Frigerio, Alessandra

AU - Lorusso, Maria Luisa

AU - Nobile, Maria

AU - Molteni, Massimo

AU - Battaglia, Marco

PY - 2004/9

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N2 - In a pilot study of 120 children with reading disabilities, we assessed the presence of linkage and association between the DRD2/Taql and the DRD4/48bp-repeat polymorphisms and quantitative measures of behavioral problems derived from parental rated Child Behavior Checklist (CBCL) [Achenbach, T. M. (1991). TM Manual for the CBCL 14-18. Burlington, VT: University of Vermont]. Analyses included measures of between-family association, and a test of the presence of linkage and association by a logistic regression-based extension of the Transmission Disequilibrium Test (i.e., the logistic regression quantitative TDT). In between-family association analyses the "Social Problem" scale was weakly associated with the number of risk alleles of DRD2 and DRD4, while the "Withdrawn" scale was related to the number of risk alleles of DRD4 (the 7-repeat and the A1 allele respectively were considered the risk alleles). Logistic regression quantitative TDTs yielded statistically significant evidence in favor of linkage and association between DRD2 and "Social Problems" (Wald χ 2 = 4.13, df = 1, p = 0.042, Odds Ratio = 1.97). A statistical trend in favor of linkage and association was found for "Withdrawn" and DRD4 (Wald χ 2 = 2.65, df = 1, p = 0.104, Odds Ratio =1.44). Although preliminary, these findings are consistent with previous data that suggest a role of the same polymorphism in influencing individual sensitivity to reward and response to social cues and reinforcements in man and animal.

AB - In a pilot study of 120 children with reading disabilities, we assessed the presence of linkage and association between the DRD2/Taql and the DRD4/48bp-repeat polymorphisms and quantitative measures of behavioral problems derived from parental rated Child Behavior Checklist (CBCL) [Achenbach, T. M. (1991). TM Manual for the CBCL 14-18. Burlington, VT: University of Vermont]. Analyses included measures of between-family association, and a test of the presence of linkage and association by a logistic regression-based extension of the Transmission Disequilibrium Test (i.e., the logistic regression quantitative TDT). In between-family association analyses the "Social Problem" scale was weakly associated with the number of risk alleles of DRD2 and DRD4, while the "Withdrawn" scale was related to the number of risk alleles of DRD4 (the 7-repeat and the A1 allele respectively were considered the risk alleles). Logistic regression quantitative TDTs yielded statistically significant evidence in favor of linkage and association between DRD2 and "Social Problems" (Wald χ 2 = 4.13, df = 1, p = 0.042, Odds Ratio = 1.97). A statistical trend in favor of linkage and association was found for "Withdrawn" and DRD4 (Wald χ 2 = 2.65, df = 1, p = 0.104, Odds Ratio =1.44). Although preliminary, these findings are consistent with previous data that suggest a role of the same polymorphism in influencing individual sensitivity to reward and response to social cues and reinforcements in man and animal.

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