An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15

Françoise Bachelerie, Gerard J. Graham, Massimo Locati, Alberto Mantovani, Philip M. Murphy, Robert Nibbs, Antal Rot, Silvano Sozzani, Marcus Thelen

Research output: Contribution to journalArticle

Abstract

Chemokines and their receptors are essential regulators of in vivo leukocyte migration and, some years ago, a systematic nomenclature system was developed for the chemokine receptor family. Chemokine receptor biology and biochemistry was recently extensively reviewed. In this review, we also highlighted a new component to the nomenclature system that incorporates receptors previously known as 'scavenging', or 'decoy', chemokine receptors on the basis of their lack of classical signalling responses to ligand binding and their general ability to scavenge, or sequester, their cognate chemokine ligands. These molecules are now collectively referred to as 'atypical chemokine receptors', or ACKRs, and play fundamental roles in regulating in vivo responses to chemokines. This commentary highlights this new addition to the chemokine receptor nomenclature system and provides brief information on the four receptors currently covered by this nomenclature.

Original languageEnglish
Pages (from-to)3945-3949
Number of pages5
JournalBritish Journal of Pharmacology
Volume172
Issue number16
DOIs
Publication statusPublished - Aug 1 2015

ASJC Scopus subject areas

  • Pharmacology

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