An automatic contour propagation method to follow parotid gland deformation during head-and-neck cancer tomotherapy

E. Faggiano, C. Fiorino, E. Scalco, S. Broggi, M. Cattaneo, E. Maggiulli, I. Dell'oca, N. Di Muzio, R. Calandrino, G. Rizzo

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We developed an efficient technique to auto-propagate parotid gland contours from planning kVCT to daily MVCT images of head-and-neck cancer patients treated with helical tomotherapy. The method deformed a 3D surface mesh constructed from manual kVCT contours by B-spline free-form deformation to generate optimal and smooth contours. Deformation was calculated by elastic image registration between kVCT and MVCT images. Data from ten head-and-neck cancer patients were considered and manual contours by three observers were included in both kVCT and MVCT images. A preliminary inter-observer variability analysis demonstrated the importance of contour propagation in tomotherapy application: a high variability was reported in MVCT parotid volume estimation (p = 0.0176, ANOVA test) and a larger uncertainty of MVCT contouring compared with kVCT was demonstrated by DICE and volume variability indices (Wilcoxon signed rank test, p <10-4 for both indices). The performance analysis of our method showed no significant differences between automatic and manual contours in terms of volumes (p > 0.05, in a multiple comparison Tukey test), center-of-mass distances (p = 0.3043, ANOVA test), DICE values (p = 0.1672, Wilcoxon signed rank test) and average and maximum symmetric distances (p = 0.2043, p = 0.8228 Wilcoxon signed rank tests). Results suggested that our contour propagation method could successfully substitute human contouring on MVCT images.

Original languageEnglish
Pages (from-to)775-791
Number of pages17
JournalPhysics in Medicine and Biology
Volume56
Issue number3
DOIs
Publication statusPublished - Feb 7 2011

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Parotid Gland
Head and Neck Neoplasms
Nonparametric Statistics
Analysis of Variance
Intensity-Modulated Radiotherapy
Observer Variation
Uncertainty

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

An automatic contour propagation method to follow parotid gland deformation during head-and-neck cancer tomotherapy. / Faggiano, E.; Fiorino, C.; Scalco, E.; Broggi, S.; Cattaneo, M.; Maggiulli, E.; Dell'oca, I.; Di Muzio, N.; Calandrino, R.; Rizzo, G.

In: Physics in Medicine and Biology, Vol. 56, No. 3, 07.02.2011, p. 775-791.

Research output: Contribution to journalArticle

Faggiano, E. ; Fiorino, C. ; Scalco, E. ; Broggi, S. ; Cattaneo, M. ; Maggiulli, E. ; Dell'oca, I. ; Di Muzio, N. ; Calandrino, R. ; Rizzo, G. / An automatic contour propagation method to follow parotid gland deformation during head-and-neck cancer tomotherapy. In: Physics in Medicine and Biology. 2011 ; Vol. 56, No. 3. pp. 775-791.
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