An E7-based therapeutic vaccine protects mice against HPV16 associated cancer

Aldo Venuti, Silvia Massa, Vadim Mett, Laura Dalla Vedova, Francesca Paolini, Rosella Franconi, Vidadi Yusibov

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Plant-derived vaccines represent an attractive strategy for cancer immunotherapy due to their relative safety and cost-effectiveness. We evaluated the anti-tumour activity of a Nicotiana benthamiana produced vaccine candidate based on the non-transforming E7 protein of HPV-16 fused to β-1,3-1,4-glucanase of Clostridium thermocellum. Two doses of vaccine at two week intervals were administered to groups of C57BL/6 mice starting 3 or 6 days after challenge with tumourigenic E7-expressing TC-1* cells. Inhibition of tumour growth and increased survival was observed in both groups treated with vaccine. These data suggest the potential of plants as a platform for producing therapeutic vaccines.

Original languageEnglish
Pages (from-to)3395-3397
Number of pages3
JournalVaccine
Volume27
Issue number25-26
DOIs
Publication statusPublished - May 26 2009

Fingerprint

Vaccines
vaccines
therapeutics
neoplasms
mice
Neoplasms
Clostridium thermocellum
Human papillomavirus 16
Therapeutics
Nicotiana benthamiana
immunotherapy
cost effectiveness
Inbred C57BL Mouse
Immunotherapy
Tobacco
Cost-Benefit Analysis
Safety
Growth
dosage
proteins

Keywords

  • Cancer vaccine
  • Human papilloma virus
  • Plant-produced vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Venuti, A., Massa, S., Mett, V., Vedova, L. D., Paolini, F., Franconi, R., & Yusibov, V. (2009). An E7-based therapeutic vaccine protects mice against HPV16 associated cancer. Vaccine, 27(25-26), 3395-3397. https://doi.org/10.1016/j.vaccine.2009.01.068

An E7-based therapeutic vaccine protects mice against HPV16 associated cancer. / Venuti, Aldo; Massa, Silvia; Mett, Vadim; Vedova, Laura Dalla; Paolini, Francesca; Franconi, Rosella; Yusibov, Vidadi.

In: Vaccine, Vol. 27, No. 25-26, 26.05.2009, p. 3395-3397.

Research output: Contribution to journalArticle

Venuti, A, Massa, S, Mett, V, Vedova, LD, Paolini, F, Franconi, R & Yusibov, V 2009, 'An E7-based therapeutic vaccine protects mice against HPV16 associated cancer', Vaccine, vol. 27, no. 25-26, pp. 3395-3397. https://doi.org/10.1016/j.vaccine.2009.01.068
Venuti A, Massa S, Mett V, Vedova LD, Paolini F, Franconi R et al. An E7-based therapeutic vaccine protects mice against HPV16 associated cancer. Vaccine. 2009 May 26;27(25-26):3395-3397. https://doi.org/10.1016/j.vaccine.2009.01.068
Venuti, Aldo ; Massa, Silvia ; Mett, Vadim ; Vedova, Laura Dalla ; Paolini, Francesca ; Franconi, Rosella ; Yusibov, Vidadi. / An E7-based therapeutic vaccine protects mice against HPV16 associated cancer. In: Vaccine. 2009 ; Vol. 27, No. 25-26. pp. 3395-3397.
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