An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

S. Mantegani; E. Arlandini; E. Brambilla; P. Cremonesi; M. Varasi

An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

S. Mantegani, E. Arlandini, E. Brambilla, P. Cremonesi, M. Varasi

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

Original language	English
Pages (from-to)	3543-3553
Number of pages	11
Journal	Synthetic Communications
Volume	30
Issue number	19
Publication status	Published - 2000

ASJC Scopus subject areas

Organic Chemistry

Cite this

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abstract = "A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.",

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AU - Mantegani, S.

AU - Arlandini, E.

AU - Brambilla, E.

AU - Cremonesi, P.

AU - Varasi, M.

PY - 2000

Y1 - 2000

N2 - A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

AB - A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

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An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

Abstract

ASJC Scopus subject areas

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