An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

S. Mantegani; E. Arlandini; E. Brambilla; P. Cremonesi; M. Varasi

An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

S. Mantegani, E. Arlandini, E. Brambilla, P. Cremonesi, M. Varasi

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

Original language	English
Pages (from-to)	3543-3553
Number of pages	11
Journal	Synthetic Communications
Volume	30
Issue number	19
Publication status	Published - 2000

ASJC Scopus subject areas

Organic Chemistry

Fingerprint Dive into the research topics of 'An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil'. Together they form a unique fingerprint.

Cite this

@article{390304b151224f01b271bf7cf5d3ebf2,

title = "An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil",

abstract = "A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.",

author = "S. Mantegani and E. Arlandini and E. Brambilla and P. Cremonesi and M. Varasi",

year = "2000",

language = "English",

volume = "30",

pages = "3543--3553",

journal = "Synthetic Communications",

issn = "0039-7911",

publisher = "Taylor and Francis Ltd.",

number = "19",

}

TY - JOUR

T1 - An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

AU - Mantegani, S.

AU - Arlandini, E.

AU - Brambilla, E.

AU - Cremonesi, P.

AU - Varasi, M.

PY - 2000

Y1 - 2000

N2 - A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

AB - A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

UR - http://www.scopus.com/inward/record.url?scp=0033850709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033850709&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0033850709

VL - 30

SP - 3543

EP - 3553

JO - Synthetic Communications

JF - Synthetic Communications

SN - 0039-7911

IS - 19

ER -

An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

Abstract

ASJC Scopus subject areas

Other files and links

Cite this