An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

S. Mantegani, E. Arlandini, E. Brambilla, P. Cremonesi, M. Varasi

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Abstract

A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

Original languageEnglish
Pages (from-to)3543-3553
Number of pages11
JournalSynthetic Communications
Volume30
Issue number19
Publication statusPublished - 2000

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Mantegani, S., Arlandini, E., Brambilla, E., Cremonesi, P., & Varasi, M. (2000). An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil. Synthetic Communications, 30(19), 3543-3553.