Abstract
A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.
Original language | English |
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Pages (from-to) | 3543-3553 |
Number of pages | 11 |
Journal | Synthetic Communications |
Volume | 30 |
Issue number | 19 |
Publication status | Published - 2000 |
ASJC Scopus subject areas
- Organic Chemistry