An easy entry to (1S, 2S) and (1R, 2R)-threo-Ifenprodil

S. Mantegani, E. Arlandini, E. Brambilla, P. Cremonesi, M. Varasi

Research output: Contribution to journalArticlepeer-review


A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1, 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

Original languageEnglish
Pages (from-to)3543-3553
Number of pages11
JournalSynthetic Communications
Issue number19
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Organic Chemistry


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