Efficacia della profilassi della trombosi venosa profonda nell'artroprotesi totale d'anca. Studio di pazienti con e senza fattori di rischio aggiuntivi

Translated title of the contribution: An effective method to prevent deep venous thrombosis in total hip artroplasty: A study in patients with and without risk factours for thrombotic desease

Enrico Pola, P. Papaleo, S. Cerciello, A. G. Aulisa, O. Mazza, L. Aulisa

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study was to determine a safe and effective method of prophylaxis for thromboembolis diseases after THA. Materials and Methods: This study was conducted on 157 patients consecutively admitted to our Department of Orthopedics to undergo elective THA from October 2000 o May 2001. We have preoperatively investigated plasma levels of homocysteine, AT III activity, Fibrinogen levels, Anticardiolipin antibodies, and circulating vWFag D-dimer levels were measured by Asserachrom D-dimer ELISA preoperatively and on day 4 postoperatively. Thromboprophylactic regimen was based on a prolonged subcutaneneus administration of nadroparin (for 40 days after surgery) and was used in all patients, with a dose based on body weight. Compression ultrasonography was udes as screening test for the diagnosis of deep venous thrombosis and perfomed in each patient on postoperative day 4, 15, and 30. Results: Although all patients enrolled in this study showed increased risk for thrombotic disease, none oh them developed either symptomatic or asymptomatic deep venous thrombosis. No complications were observed, including major bleeding or abnormalities of laboratory tests. Conclusions: Our study indicates that prolonged thromboprophylaxis with nadroparin for 40 days postoperatively, associated with early mobilization, is an effective and safe protocol of antithrombotic prophylaxis in patients operated for THA with and without risk factors for thrombotic disease.

Translated title of the contributionAn effective method to prevent deep venous thrombosis in total hip artroplasty: A study in patients with and without risk factours for thrombotic desease
Original languageItalian
Pages (from-to)151-157
Number of pages7
JournalClinica Terapeutica
Volume154
Issue number3
Publication statusPublished - May 2003

ASJC Scopus subject areas

  • Medicine(all)

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