TY - JOUR
T1 - An electrophysiological study of D2 dopaminergic actions in normal human retina
T2 - A tool in Parkinson's disease
AU - Stanzione, Paolo
AU - Traversa, Raimondo
AU - Pierantozzi, Mariangela
AU - Semprini, Roberta
AU - Marciani, Maria Grazia
AU - Bernardi, Giorgio
PY - 1992/6/8
Y1 - 1992/6/8
N2 - A peculiar deficit of electrophysiological retinal responses to pattern reversal grating stimuli has been reported in Parkinson's disease (PD) patients. A similar abnormality has been reproduced by means of non-selective dopaminergic antagonists in normal humans. Aim of this study was to verify, by means of a selective D2 antagonist (sulpiride) administered to normal subjects, whether a D2 blockade affects the visual electrophysiological performances with the same trend as observed in PD patients. Pattern electroretinogram (PERG) responses to 1 cycle per degree (c/d) of spatial frequency at 1 (transient) and 7.5 (steady state) Hz of temporal modulation of a square-wave grating pattern reversal have been recorded in 19 healthy volunteers before and after the administration of 100 mg i.m. of sulpiride. The data are consistent for the following conclusion: a selective D2 antagonist reduces steady state and delays transient retinal responses as expected for a PD mimicking agent.
AB - A peculiar deficit of electrophysiological retinal responses to pattern reversal grating stimuli has been reported in Parkinson's disease (PD) patients. A similar abnormality has been reproduced by means of non-selective dopaminergic antagonists in normal humans. Aim of this study was to verify, by means of a selective D2 antagonist (sulpiride) administered to normal subjects, whether a D2 blockade affects the visual electrophysiological performances with the same trend as observed in PD patients. Pattern electroretinogram (PERG) responses to 1 cycle per degree (c/d) of spatial frequency at 1 (transient) and 7.5 (steady state) Hz of temporal modulation of a square-wave grating pattern reversal have been recorded in 19 healthy volunteers before and after the administration of 100 mg i.m. of sulpiride. The data are consistent for the following conclusion: a selective D2 antagonist reduces steady state and delays transient retinal responses as expected for a PD mimicking agent.
KW - Dopamine
KW - Dopamine D receptor
KW - Normal human
KW - Parkinson's disease
KW - Pattern electroretinogram
KW - Retina
KW - Sulpiride
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U2 - 10.1016/0304-3940(92)90697-6
DO - 10.1016/0304-3940(92)90697-6
M3 - Article
C2 - 1407691
AN - SCOPUS:0026611120
VL - 140
SP - 125
EP - 128
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -