An emerging role for long non-coding RNA dysregulation in neurological disorders

Research output: Contribution to journalArticle

Abstract

A novel class of transcripts, long non coding RNAs (lncRNAs), has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered.

Original languageEnglish
Pages (from-to)20427-20442
Number of pages16
JournalInternational Journal of Molecular Sciences
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 14 2013

Keywords

  • Epigenetics
  • LncRNA
  • Neurodegenerative diseases
  • RNA

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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