An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis

F. Pisani, A. Fazio, C. Artesi, G. Oteri, B. Pisani, F. Romano, E. Perucca, R. Di Perri

Research output: Contribution to journalArticle

Abstract

The impact of pharmacokinetic anticonvulsant drug interactions on prescribing patterns and serum drug level distribution in a routine clinical setting was evaluated in a population of 848 patients chronically treated with phenytoin, phenobarbital, carbamazepine and valproic acid (either alone or as two-drug combinations) and referred for therapeutic drug monitoring for the first time. While dosages of each drug did not differ significantly between monotherapy and polytherapy patients, significant differences in serum level distribution were found. The proportion of patients with suboptimal serum carbamazepine and valproic acid levels (

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalItalian Journal of Neurological Sciences
Volume8
Issue number2
DOIs
Publication statusPublished - Apr 1987

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Drug Interactions
Anticonvulsants
Epidemiologic Studies
Pharmacokinetics
Carbamazepine
Valproic Acid
Serum
Pharmaceutical Preparations
Drug Monitoring
Phenytoin
Drug Combinations
Phenobarbital
Population

Keywords

  • Antiepiletic drug interation
  • Clinical
  • Epidemiology
  • Impact

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis. / Pisani, F.; Fazio, A.; Artesi, C.; Oteri, G.; Pisani, B.; Romano, F.; Perucca, E.; Di Perri, R.

In: Italian Journal of Neurological Sciences, Vol. 8, No. 2, 04.1987, p. 135-141.

Research output: Contribution to journalArticle

Pisani, F. ; Fazio, A. ; Artesi, C. ; Oteri, G. ; Pisani, B. ; Romano, F. ; Perucca, E. ; Di Perri, R. / An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis. In: Italian Journal of Neurological Sciences. 1987 ; Vol. 8, No. 2. pp. 135-141.
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