The relationship of benign breast disease (BBD) and oral contraceptives (OC) use was analysed in a case-control study conducted in Milan on 288 women with clinically relevant and histologically confirmed BBD (cases) and 285 age matched controls with a spectrum of acute conditions apparently unrelated to OC use. Compared to women who had never used oral contraceptives, the relative risk (RR) for users was 1.0 (95% confidence interval: 0.6 - 1.5). Likewise, there was no significant association with duration of use; however, a significantly lower relative risk emerged in women taking OC during the year before breast biopsy (RR = 0.4, 95% confidence interval: 0.2-0.8). The protection in current users increased with increasing duration of use. In spite of this finding, the overall results of the present study do not support the hypothesis that oral contraceptive use protects against development of histologically confirmed and clinically relevant benign breast disease.
|Number of pages||5|
|Journal||Contraception Fertilite Sexualite|
|Publication status||Published - 1986|
ASJC Scopus subject areas
- Obstetrics and Gynaecology