An Epistatic Interaction between the PAX8 and STK17B Genes in Papillary Thyroid Cancer Susceptibility

Iñigo Landa, Cesar Boullosa, Lucía Inglada-Pérez, Ana Sastre-Perona, Susana Pastor, Antonia Velázquez, Veronika Mancikova, Sergio Ruiz-Llorente, Francesca Schiavi, Ricard Marcos, Nuria Malats, Giuseppe Opocher, Ramon Diaz-Uriarte, Pilar Santisteban, Alfonso Valencia, Mercedes Robledo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Papillary Thyroid Cancer (PTC) is a heterogeneous and complex disease; susceptibility to PTC is influenced by the joint effects of multiple common, low-penetrance genes, although relatively few have been identified to date. Here we applied a rigorous combined approach to assess both the individual and epistatic contributions of genetic factors to PTC susceptibility, based on one of the largest series of thyroid cancer cases described to date. In addition to identifying the involvement of TSHR variation in classic PTC, our pioneer study of epistasis revealed a significant interaction between variants in STK17B and PAX8. The interaction was detected by MD-MBR (p = 0.00010) and confirmed by other methods, and then replicated in a second independent series of patients (MD-MBR p = 0.017). Furthermore, we demonstrated an inverse correlation between expression of PAX8 and STK17B in a set of cell lines derived from human thyroid carcinomas. Overall, our work sheds additional light on the genetic basis of thyroid cancer susceptibility, and suggests a new direction for the exploration of the inherited genetic contribution to disease using association studies.

Original languageEnglish
Article numbere74765
JournalPLoS One
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 23 2013

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Genes
Thyroid Neoplasms
genes
Cells
Penetrance
penetrance
epistasis
Cell Line
carcinoma
Papillary Thyroid cancer
thyroid neoplasms
cell lines
Direction compound
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Landa, I., Boullosa, C., Inglada-Pérez, L., Sastre-Perona, A., Pastor, S., Velázquez, A., ... Robledo, M. (2013). An Epistatic Interaction between the PAX8 and STK17B Genes in Papillary Thyroid Cancer Susceptibility. PLoS One, 8(9), [e74765]. https://doi.org/10.1371/journal.pone.0074765

An Epistatic Interaction between the PAX8 and STK17B Genes in Papillary Thyroid Cancer Susceptibility. / Landa, Iñigo; Boullosa, Cesar; Inglada-Pérez, Lucía; Sastre-Perona, Ana; Pastor, Susana; Velázquez, Antonia; Mancikova, Veronika; Ruiz-Llorente, Sergio; Schiavi, Francesca; Marcos, Ricard; Malats, Nuria; Opocher, Giuseppe; Diaz-Uriarte, Ramon; Santisteban, Pilar; Valencia, Alfonso; Robledo, Mercedes.

In: PLoS One, Vol. 8, No. 9, e74765, 23.09.2013.

Research output: Contribution to journalArticle

Landa, I, Boullosa, C, Inglada-Pérez, L, Sastre-Perona, A, Pastor, S, Velázquez, A, Mancikova, V, Ruiz-Llorente, S, Schiavi, F, Marcos, R, Malats, N, Opocher, G, Diaz-Uriarte, R, Santisteban, P, Valencia, A & Robledo, M 2013, 'An Epistatic Interaction between the PAX8 and STK17B Genes in Papillary Thyroid Cancer Susceptibility', PLoS One, vol. 8, no. 9, e74765. https://doi.org/10.1371/journal.pone.0074765
Landa I, Boullosa C, Inglada-Pérez L, Sastre-Perona A, Pastor S, Velázquez A et al. An Epistatic Interaction between the PAX8 and STK17B Genes in Papillary Thyroid Cancer Susceptibility. PLoS One. 2013 Sep 23;8(9). e74765. https://doi.org/10.1371/journal.pone.0074765
Landa, Iñigo ; Boullosa, Cesar ; Inglada-Pérez, Lucía ; Sastre-Perona, Ana ; Pastor, Susana ; Velázquez, Antonia ; Mancikova, Veronika ; Ruiz-Llorente, Sergio ; Schiavi, Francesca ; Marcos, Ricard ; Malats, Nuria ; Opocher, Giuseppe ; Diaz-Uriarte, Ramon ; Santisteban, Pilar ; Valencia, Alfonso ; Robledo, Mercedes. / An Epistatic Interaction between the PAX8 and STK17B Genes in Papillary Thyroid Cancer Susceptibility. In: PLoS One. 2013 ; Vol. 8, No. 9.
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