An Estimate of Attributable Cases of Alzheimer Disease and Vascular Dementia due to Modifiable Risk Factors: The Impact of Primary Prevention in Europe and in Italy

Flavia Mayer, Alessandra Di Pucchio, Eleonora Lacorte, Ilaria Bacigalupo, Fabrizio Marzolini, Gianluigi Ferrante, Valentina Minardi, Maria Masocco, Marco Canevelli, Teresa Di Fiandra, Nicola Vanacore

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Up to 53.7% of all cases of dementia are assumed to be due to Alzheimer disease (AD), while 15.8% are considered to be due to vascular dementia (VaD). In Europe, about 3 million cases of AD could be due to 7 potentially modifiable risk factors: diabetes, midlife hypertension and/or obesity, physical inactivity, depression, smoking, and low educational level.

Aims: To estimate the number of VaD cases in Europe and the number of AD and VaD cases in Italy attributable to these 7 potentially modifiable risk factors.

Methods: Assuming the nonindependence of the 7 risk factors, the adjusted combined population attributable risk (PAR) was estimated for AD and VaD.

Results: In Europe, adjusted combined PAR was 31.4% for AD and 37.8% for VaD. The total number of attributable cases was 3,033,000 for AD and 873,000 for VaD. In Italy, assuming a 20% reduction of the prevalence of each risk factor, adjusted combined PAR decreased from 45.2 to 38.9% for AD and from 53.1 to 46.6% for VaD, implying a 6.4 and 6.5% reduction in the prevalence of AD and VaD, respectively.

Conclusion: A relevant reduction of AD and VaD cases in Europe and Italy could be obtained through primary prevention.

Original languageEnglish
Pages (from-to)60-71
Number of pages12
JournalDementia and Geriatric Cognitive Disorders Extra
Volume8
Issue number1
DOIs
Publication statusPublished - Apr 3 2018

Fingerprint Dive into the research topics of 'An Estimate of Attributable Cases of Alzheimer Disease and Vascular Dementia due to Modifiable Risk Factors: The Impact of Primary Prevention in Europe and in Italy'. Together they form a unique fingerprint.

Cite this