An evaluation of γ-glutamyl dipeptide derivatives as antagonists of amino acid-induced Na+ fluxes in rat striatum slices

N. Tal, O. Goldberg, A. Luini, V. I. Teichberg

Research output: Contribution to journalArticlepeer-review

Abstract

Various γ-glutamyl dipeptide derivatives of the L and D configuration were tested as antagonists of excitatory amino acid-induced [22Na+] efflux from rat striatum slices. The N-methyl-D-aspartate- and kainic acid-induced responses were much more affected by the presence of these peptides than were the L-glutamate-, L-aspartate-, and quisqualate-induced responses. The dipeptides produced different patterns of antagonism of the responses to N-methyl-D-aspartate and kainic acid, indicating that these latter excitants interact with distinct receptors.

Original languageEnglish
Pages (from-to)574-576
Number of pages3
JournalJournal of Neurochemistry
Volume39
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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