Various γ-glutamyl dipeptide derivatives of the L and D configuration were tested as antagonists of excitatory amino acid-induced [22Na+] efflux from rat striatum slices. The N-methyl-D-aspartate- and kainic acid-induced responses were much more affected by the presence of these peptides than were the L-glutamate-, L-aspartate-, and quisqualate-induced responses. The dipeptides produced different patterns of antagonism of the responses to N-methyl-D-aspartate and kainic acid, indicating that these latter excitants interact with distinct receptors.
|Number of pages||3|
|Journal||Journal of Neurochemistry|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience