An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry

P. Zentilin, P. Dulbecco, E. Savarino, A. Parodi, E. Iiritano, C. Bilardi, S. Reglioni, S. Vigneri, V. Savarino

Research output: Contribution to journalArticle

Abstract

Background: Alginate-based preparations act as mechanical antireflux barrier, which can reduce both acid and non-acid reflux events and limit the proximal migration of oesophageal refluxate. Aim: To evaluate all the above features with a novel technique, multichannel electrical impedance and pH-metry. Methods: Ten reflux patients underwent stationary impedancemetry and pH-metry after eating a refluxogenic meal. They were studied 1 h in basal conditions and 1 h after taking 10 mL of Gaviscon Advance. In both sessions, measurements were obtained in right lateral and supine decubitus. Results: Alginate preparation was able to decrease significantly (P <0.05) the number of acid reflux events and the percentage time pH <4.0 compared with baseline. There was no effect of the drug on non-acid refluxes. Gaviscon Advance was also significantly effective (P <0.05) in reducing the height of proximal migration of reflux events compared with baseline in both decubitus positions. Conclusions: Our findings explain how Gaviscon Advance controls acid reflux episodes, limits the proximal migration of refluxed material and thereby decreases symptoms in clinical practice.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalAlimentary Pharmacology and Therapeutics
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Zentilin, P., Dulbecco, P., Savarino, E., Parodi, A., Iiritano, E., Bilardi, C., Reglioni, S., Vigneri, S., & Savarino, V. (2005). An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry. Alimentary Pharmacology and Therapeutics, 21(1), 29-34. https://doi.org/10.1111/j.1365-2036.2004.02298.x