An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry

P. Zentilin, P. Dulbecco, E. Savarino, A. Parodi, E. Iiritano, C. Bilardi, S. Reglioni, S. Vigneri, V. Savarino

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: Alginate-based preparations act as mechanical antireflux barrier, which can reduce both acid and non-acid reflux events and limit the proximal migration of oesophageal refluxate. Aim: To evaluate all the above features with a novel technique, multichannel electrical impedance and pH-metry. Methods: Ten reflux patients underwent stationary impedancemetry and pH-metry after eating a refluxogenic meal. They were studied 1 h in basal conditions and 1 h after taking 10 mL of Gaviscon Advance. In both sessions, measurements were obtained in right lateral and supine decubitus. Results: Alginate preparation was able to decrease significantly (P <0.05) the number of acid reflux events and the percentage time pH <4.0 compared with baseline. There was no effect of the drug on non-acid refluxes. Gaviscon Advance was also significantly effective (P <0.05) in reducing the height of proximal migration of reflux events compared with baseline in both decubitus positions. Conclusions: Our findings explain how Gaviscon Advance controls acid reflux episodes, limits the proximal migration of refluxed material and thereby decreases symptoms in clinical practice.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalAlimentary Pharmacology and Therapeutics
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

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Electric Impedance
Acids
Meals
Eating
Pharmaceutical Preparations
alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination
alginic acid

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry. / Zentilin, P.; Dulbecco, P.; Savarino, E.; Parodi, A.; Iiritano, E.; Bilardi, C.; Reglioni, S.; Vigneri, S.; Savarino, V.

In: Alimentary Pharmacology and Therapeutics, Vol. 21, No. 1, 01.01.2005, p. 29-34.

Research output: Contribution to journalArticle

Zentilin, P, Dulbecco, P, Savarino, E, Parodi, A, Iiritano, E, Bilardi, C, Reglioni, S, Vigneri, S & Savarino, V 2005, 'An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry', Alimentary Pharmacology and Therapeutics, vol. 21, no. 1, pp. 29-34. https://doi.org/10.1111/j.1365-2036.2004.02298.x
Zentilin, P. ; Dulbecco, P. ; Savarino, E. ; Parodi, A. ; Iiritano, E. ; Bilardi, C. ; Reglioni, S. ; Vigneri, S. ; Savarino, V. / An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry. In: Alimentary Pharmacology and Therapeutics. 2005 ; Vol. 21, No. 1. pp. 29-34.
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