An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies

Jay H. Lubin, Joshua Muscat, Mia M. Gaudet, Andrew F. Olshan, Maria Paula Curado, Luigino Dal Maso, Victor Wünsch-Filho, Erich M. Sturgis, Neonilia Szeszenia-Dabrowska, Xavier Castellsague, Zuo Feng Zhang, Elaine Smith, Leticia Fernandez, Elena Matos, Silvia Franceschi, Eleonora Fabianova, Peter Rudnai, Mark P. Purdue, Dana Mates, Qingyi WeiRolando Herrero, Karl Kelsey, Hal Morgenstern, Oxana Shangina, Sergio Koifman, Jolanta Lissowska, Fabio Levi, Alexander W. Daudt, Jose Eluf Neto, Chu Chen, Philip Lazarus, Deborah M. Winn, Stephen M. Schwartz, Paolo Boffetta, Paul Brennan, Ana Menezes, Carlo La Vecchia, Michael McClean, Renato Talamini, Thangarajan Rajkumar, Richard B. Hayes, Mia Hashibe

Research output: Contribution to journalArticle

Abstract

Background: Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors. Methods: We analyzed 2,441 oral cavity (925 women and 1,516 men), 2,297 oropharynx (564 women and 1,733 men), 508 hypopharynx (96 women and 412 men), and 1,740 larynx (237 women and 1,503 men) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models. Results: ORs were increased in underweight (

Original languageEnglish
Pages (from-to)1217-1231
Number of pages15
JournalCancer Causes and Control
Volume22
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Alcohol consumption
  • Cigarette smoking
  • Interactions
  • Odds ratio models

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Lubin, J. H., Muscat, J., Gaudet, M. M., Olshan, A. F., Curado, M. P., Dal Maso, L., Wünsch-Filho, V., Sturgis, E. M., Szeszenia-Dabrowska, N., Castellsague, X., Zhang, Z. F., Smith, E., Fernandez, L., Matos, E., Franceschi, S., Fabianova, E., Rudnai, P., Purdue, M. P., Mates, D., ... Hashibe, M. (2011). An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies. Cancer Causes and Control, 22(9), 1217-1231. https://doi.org/10.1007/s10552-011-9792-x