An experimental model of myasthenia myopathy

V. Tegazzin, E. Facco, V. Caldesi Valeri, N. Bresólin, G. P. Gíron

Research output: Contribution to journalArticlepeer-review

Abstract

Normal and thymectomised rabbits were immunized by means of a thymic extract emulsified with Freund's Complete Adjuvant. The experiment was conducted over a three month period, in order to reproduce an experimental model of chronic myasthenia. During this period immunological, electromyographic and histologic studies were undertaken. Typical findings of partial neuromuscular block were invariably obtained from all the non thymectomized animals, while such signs were constantly absent both in nontreated control rabbits and in the immunized thymectomized ones. This neuromuscular block was intermittent. The compromised neuromuscular conduction was associated to an histological pattern of autoimmune myopathy. Evidence indicated antibodies directed against the thymus, muscular and nervous tissue. The results indicate the important role of the thymus gland both in altering conduction at the neuromuscular junction level and causing histopathologic muscle lesions.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalAgressologie
Volume20
Issue number5
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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