An experimental pilot study of tacalcitol activities during modulation of parakeratotic skin features.

M. G. Tucci, G. Ricotti, R. Giardino, S. Carraro, G. Mattei, I. Cataldi, G. Lucarini, R. Solmi, L. Tosi, G. Biagini

Research output: Contribution to journalArticle

Abstract

Establishing guidelines and experimental models preclinical and clinical evaluations of new agents for treatment, and/or prevention of human diseases has become a task of crucial importance. Psoriasis is such one disease holding great interest for dermatology owing to its high rate of incidence and complexity of treatment. However the absence of psoriatic lesions in animals and the inability to induce them, calls for experimental techniques both in vitro and in vivo. The purpose of this study was to evaluate experimentally the effects of tacalcitol on cell proliferation and differentiation process. Thereafter a human pilot study on psoriatic patients has been developed.

Original languageEnglish
Pages (from-to)1213-1220
Number of pages8
JournalCellular and Molecular Biology
Volume43
Issue number8
Publication statusPublished - Dec 1997

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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    Tucci, M. G., Ricotti, G., Giardino, R., Carraro, S., Mattei, G., Cataldi, I., Lucarini, G., Solmi, R., Tosi, L., & Biagini, G. (1997). An experimental pilot study of tacalcitol activities during modulation of parakeratotic skin features. Cellular and Molecular Biology, 43(8), 1213-1220.