Glycolic acid full-strength concentration is widely used as caustic substance in superficial chemical peeling. In this application the safety of glycolic acid is considered high. This substance is commercially available in different concentrations and formulations; the latterones are not justified by experimental study. For this reason some parameters, that can modify the peeling strength, have been experimentally tested in this paper. The considered parameters are: the mean concentration of glycolic acid that produces erythema, the interindividual sensitivity, the role of skin delipidization, the glycolic acid solution pH variation, the artificial thinning of the stratum corneum and the surface-active agent addition to glycolic acid solution. This experimental study reveals that there is extreme variability in the skin response to glycolic acid and that the peeling strength may be modified by changing the considered parameters. The results obtained are useful to understand glycolic acid activity and to choose the right concentration and formulation in clinical practice.
|Translated title of the contribution||An experimental study on the variability of skin response to glycolic acid application|
|Number of pages||5|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1997|
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