An exploratory case-control study on spinal and bulbar forms of amyotrophic lateral sclerosis in the province of Rome

Alessandra Binazzi, Stefano Belli, Raffaella Uccelli, Maria Teresa Desiato, Irene Fig Talamanca, Giovanni Antonini, Fabio M. Corsi, Ciriaco Scoppetta, Maurizio Inghilleri, Francesco E. Pontieri, Nicola Vanacore

Research output: Contribution to journalArticle

Abstract

Several environmental and life-style factors reported as possibly associated with ALS have been analysed in the present study, focusing on the two clinical onsets of ALS. A case-control study (77 cases and 185 controls) has been performed in the province of Rome in the period 20052006. Increased risks were observed in bulbar cases for former smokers (OR: 4.55, 90% CI 1.7212.08) and more than 24 pack-years, compared with spinal cases for employment in the construction sector and professional exposure to building materials (OR: 5.27, 90% CI 1.1524.12) and metals (OR: 2.94, 90% CI 1.207.21). Overall and bulbar cases showed an increased risk for consumption of cold cuts and a decreased risk for vegetables intake. Regarding head injuries, differences were observed if the last injury occurred in the age range of 3040 years, among all (OR: 14.2, 90% CI 1.04194.42) and bulbar (OR: 17.4, 90% CI 1.70178.5) cases, and less than 30 years among spinal cases (OR: 7.13, 90% CI 1.3437.94). Moreover, a risk for a time period of 1130 years since the last head injury suffered was found in bulbar cases (OR: 3.51, 90% CI 1.0311.95). Some of the hypothesized risk factors for ALS have been found positively associated in this study, with different patterns between bulbar and spinal ALS.

Original languageEnglish
Pages (from-to)361-369
Number of pages9
JournalAmyotrophic Lateral Sclerosis
Volume10
Issue number5-6
DOIs
Publication statusPublished - 2009

Keywords

  • Amyotrophic lateral sclerosis
  • Clinical onset
  • Risk factor
  • Trauma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Binazzi, A., Belli, S., Uccelli, R., Desiato, M. T., Talamanca, I. F., Antonini, G., Corsi, F. M., Scoppetta, C., Inghilleri, M., Pontieri, F. E., & Vanacore, N. (2009). An exploratory case-control study on spinal and bulbar forms of amyotrophic lateral sclerosis in the province of Rome. Amyotrophic Lateral Sclerosis, 10(5-6), 361-369. https://doi.org/10.3109/17482960802382313