An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain

M. Siotto, I. Aprile, I. Simonelli, C. Pazzaglia, M. Ventriglia, M. Santoro, I. Imbimbo, R. Squitti, L. Padua

Research output: Contribution to journalArticle

Abstract

Patients affected by stroke, particularly subacute stroke patients, often complain of neuropathic pain (NP), which may severely impair their quality of life. The aim of this exploratory study was to characterize NP and to investigate whether there is a correlation between NP and serum brain-derived neurotrophic factor (BDNF) and serum markers of oxidative stress. We enrolled 50 patients divided in subacute ( 90 and 180 
Original languageEnglish
Pages (from-to)1557-1566
Number of pages10
JournalJournal of Neural Transmission
Volume124
Issue number12
DOIs
Publication statusPublished - 2017

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Keywords

  • Brain-derived neurotrophic factor (BDNF)
  • Ceruloplasmin-specific activity
  • Chronic stroke
  • Cp/Tf ratio
  • Neuropathic pain
  • Subacute stroke
  • Total antioxidant status
  • brain derived neurotrophic factor
  • ceruloplasmin
  • copper
  • ferritin
  • transferrin
  • activity of daily living assessment
  • adult
  • aged
  • Article
  • Barthel index
  • cerebrovascular accident
  • chronic patient
  • controlled study
  • copper metabolism
  • correlational study
  • Deambulation Index
  • female
  • human
  • major clinical study
  • male
  • neuropathic pain
  • Neuropathic Pain Diagnostic questionnaire
  • Neuropathic Pain Symptom Inventory
  • numeric rating scale
  • oxidative stress
  • priority journal
  • protein blood level
  • quality of life
  • questionnaire
  • rehabilitation center
  • Short Form 36
  • stroke patient

Cite this

Siotto, M., Aprile, I., Simonelli, I., Pazzaglia, C., Ventriglia, M., Santoro, M., Imbimbo, I., Squitti, R., & Padua, L. (2017). An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain. Journal of Neural Transmission, 124(12), 1557-1566. https://doi.org/10.1007/s00702-017-1805-9