An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain

M. Siotto; I. Aprile; I. Simonelli; C. Pazzaglia; M. Ventriglia; M. Santoro; I. Imbimbo; R. Squitti; L. Padua

doi:10.1007/s00702-017-1805-9

An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain

M. Siotto, I. Aprile, I. Simonelli, C. Pazzaglia, M. Ventriglia, M. Santoro, I. Imbimbo, R. Squitti, L. Padua

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article

Abstract

Patients affected by stroke, particularly subacute stroke patients, often complain of neuropathic pain (NP), which may severely impair their quality of life. The aim of this exploratory study was to characterize NP and to investigate whether there is a correlation between NP and serum brain-derived neurotrophic factor (BDNF) and serum markers of oxidative stress. We enrolled 50 patients divided in subacute ( 90 and 180

Original language	English
Pages (from-to)	1557-1566
Number of pages	10
Journal	Journal of Neural Transmission
Volume	124
Issue number	12
DOIs	https://doi.org/10.1007/s00702-017-1805-9
Publication status	Published - 2017

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Keywords

Brain-derived neurotrophic factor (BDNF)
Ceruloplasmin-specific activity
Chronic stroke
Cp/Tf ratio
Neuropathic pain
Subacute stroke
Total antioxidant status
brain derived neurotrophic factor
ceruloplasmin
copper
ferritin
transferrin
activity of daily living assessment
adult
aged
Article
Barthel index
cerebrovascular accident
chronic patient
controlled study
copper metabolism
correlational study
Deambulation Index
female
human
major clinical study
male
neuropathic pain
Neuropathic Pain Diagnostic questionnaire
Neuropathic Pain Symptom Inventory
numeric rating scale
oxidative stress
priority journal
protein blood level
quality of life
questionnaire
rehabilitation center
Short Form 36
stroke patient

Cite this

Siotto, M., Aprile, I., Simonelli, I., Pazzaglia, C., Ventriglia, M., Santoro, M., Imbimbo, I., Squitti, R., & Padua, L. (2017). An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain. Journal of Neural Transmission, 124(12), 1557-1566. https://doi.org/10.1007/s00702-017-1805-9

An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain. / Siotto, M.; Aprile, I.; Simonelli, I.; Pazzaglia, C.; Ventriglia, M.; Santoro, M.; Imbimbo, I.; Squitti, R.; Padua, L.

In: Journal of Neural Transmission, Vol. 124, No. 12, 2017, p. 1557-1566.

Research output: Contribution to journal › Article

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10.1007/s00702-017-1805-9

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032669045&doi=10.1007%2fs00702-017-1805-9&partnerID=40&md5=e5632dbd4e74601cecde1299486b7521