An expression atlas of connexin genes in the mouse

Annalisa Buniello, Donatella Montanaro, Stefano Volinia, Paolo Gasparini, Valeria Marigo

Research output: Contribution to journalArticle

Abstract

Connexin genes are involved in several human diseases such as hearing and dermatological and peripheral nerve disorders. Connexins are protein units of gap junctions and form homotypic, heterotypic, or heteromeric complexes known as connexons. Data on the expression patterns of members of this family are partial and fragmentary. We therefore cloned all the identifiable murine homologs of human CONNEXIN genes and analyzed their expression patterns in embryonic and neonatal mouse tissues. We found that connexins are preferentially expressed in tissues derived from ectoderm and/or endoderm. Our data provide a comprehensive and detailed atlas of expression of connexin genes and in some cases suggest possible interactions of proteins that are coexpressed in the same tissue. Knowledge of temporal and spatial distribution of connexins also allows the identification of candidate genes for human diseases and provides important insight into mechanisms that lead to human disorders due to mutations in CONNEXIN genes.

Original languageEnglish
Pages (from-to)812-820
Number of pages9
JournalGenomics
Volume83
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Connexins
  • Expression
  • Human diseases
  • In situ hybridization
  • Mouse

ASJC Scopus subject areas

  • Genetics

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    Buniello, A., Montanaro, D., Volinia, S., Gasparini, P., & Marigo, V. (2004). An expression atlas of connexin genes in the mouse. Genomics, 83(5), 812-820. https://doi.org/10.1016/j.ygeno.2003.10.011