Abstract
Compared to conventional deep brain stimulation (DBS) for patients with Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating stimulation on the basis of the patient's clinical state, promises to achieve better clinical outcomes, avoid adverse-effects and save time for tuning parameters. A remaining challenge before aDBS comes into practical use is to prove its feasibility and its effectiveness in larger groups of patients and in more ecological conditions. We developed an external portable aDBS system prototype designed for clinical testing in freely-moving PD patients with externalized DBS electrodes. From a single-channel bipolar artifact-free recording, it analyses local field potentials (LFPs), during ongoing DBS for tuning stimulation parameters, independent from the specific feedback algorithm implemented. We validated the aDBS system in vitro, by testing both its sensing and closed-loop stimulation capabilities, and then tested it in vivo, focusing on the sensing capabilities. By applying the aDBS system prototype in a patient with PD, we provided evidence that it can track levodopa and DBS-induced LFP spectral power changes among different patient's clinical states. Our system, intended for testing LFP-based feedback strategies for aDBS, should help understanding how and whether aDBS therapy works in PD and indicating future technical and clinical advances.
| Original language | English |
|---|---|
| Pages (from-to) | 498-505 |
| Number of pages | 8 |
| Journal | Medical Engineering and Physics |
| Volume | 38 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 1 2016 |
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Keywords
- Adaptive deep brain stimulation
- Closed loop stimulation
- Local field potentials
- Parkinson's Disease
ASJC Scopus subject areas
- Biomedical Engineering
- Biophysics
Cite this
An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson's Disease. / Arlotti, Mattia; Rossi, Lorenzo; Rosa, Manuela; Marceglia, Sara; Priori, Alberto.
In: Medical Engineering and Physics, Vol. 38, No. 5, 01.05.2016, p. 498-505.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson's Disease
AU - Arlotti, Mattia
AU - Rossi, Lorenzo
AU - Rosa, Manuela
AU - Marceglia, Sara
AU - Priori, Alberto
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Compared to conventional deep brain stimulation (DBS) for patients with Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating stimulation on the basis of the patient's clinical state, promises to achieve better clinical outcomes, avoid adverse-effects and save time for tuning parameters. A remaining challenge before aDBS comes into practical use is to prove its feasibility and its effectiveness in larger groups of patients and in more ecological conditions. We developed an external portable aDBS system prototype designed for clinical testing in freely-moving PD patients with externalized DBS electrodes. From a single-channel bipolar artifact-free recording, it analyses local field potentials (LFPs), during ongoing DBS for tuning stimulation parameters, independent from the specific feedback algorithm implemented. We validated the aDBS system in vitro, by testing both its sensing and closed-loop stimulation capabilities, and then tested it in vivo, focusing on the sensing capabilities. By applying the aDBS system prototype in a patient with PD, we provided evidence that it can track levodopa and DBS-induced LFP spectral power changes among different patient's clinical states. Our system, intended for testing LFP-based feedback strategies for aDBS, should help understanding how and whether aDBS therapy works in PD and indicating future technical and clinical advances.
AB - Compared to conventional deep brain stimulation (DBS) for patients with Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating stimulation on the basis of the patient's clinical state, promises to achieve better clinical outcomes, avoid adverse-effects and save time for tuning parameters. A remaining challenge before aDBS comes into practical use is to prove its feasibility and its effectiveness in larger groups of patients and in more ecological conditions. We developed an external portable aDBS system prototype designed for clinical testing in freely-moving PD patients with externalized DBS electrodes. From a single-channel bipolar artifact-free recording, it analyses local field potentials (LFPs), during ongoing DBS for tuning stimulation parameters, independent from the specific feedback algorithm implemented. We validated the aDBS system in vitro, by testing both its sensing and closed-loop stimulation capabilities, and then tested it in vivo, focusing on the sensing capabilities. By applying the aDBS system prototype in a patient with PD, we provided evidence that it can track levodopa and DBS-induced LFP spectral power changes among different patient's clinical states. Our system, intended for testing LFP-based feedback strategies for aDBS, should help understanding how and whether aDBS therapy works in PD and indicating future technical and clinical advances.
KW - Adaptive deep brain stimulation
KW - Closed loop stimulation
KW - Local field potentials
KW - Parkinson's Disease
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U2 - 10.1016/j.medengphy.2016.02.007
DO - 10.1016/j.medengphy.2016.02.007
M3 - Article
VL - 38
SP - 498
EP - 505
JO - Medical Engineering and Physics
JF - Medical Engineering and Physics
SN - 1350-4533
IS - 5
ER -