An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson's Disease

Mattia Arlotti, Lorenzo Rossi, Manuela Rosa, Sara Marceglia, Alberto Priori

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Compared to conventional deep brain stimulation (DBS) for patients with Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating stimulation on the basis of the patient's clinical state, promises to achieve better clinical outcomes, avoid adverse-effects and save time for tuning parameters. A remaining challenge before aDBS comes into practical use is to prove its feasibility and its effectiveness in larger groups of patients and in more ecological conditions. We developed an external portable aDBS system prototype designed for clinical testing in freely-moving PD patients with externalized DBS electrodes. From a single-channel bipolar artifact-free recording, it analyses local field potentials (LFPs), during ongoing DBS for tuning stimulation parameters, independent from the specific feedback algorithm implemented. We validated the aDBS system in vitro, by testing both its sensing and closed-loop stimulation capabilities, and then tested it in vivo, focusing on the sensing capabilities. By applying the aDBS system prototype in a patient with PD, we provided evidence that it can track levodopa and DBS-induced LFP spectral power changes among different patient's clinical states. Our system, intended for testing LFP-based feedback strategies for aDBS, should help understanding how and whether aDBS therapy works in PD and indicating future technical and clinical advances.

Original languageEnglish
Pages (from-to)498-505
Number of pages8
JournalMedical Engineering and Physics
Volume38
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Deep Brain Stimulation
Parkinson Disease
Brain
Equipment and Supplies
Research
Testing
Tuning
Feedback
Levodopa
Artifacts
Electrodes

Keywords

  • Adaptive deep brain stimulation
  • Closed loop stimulation
  • Local field potentials
  • Parkinson's Disease

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

Cite this

An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson's Disease. / Arlotti, Mattia; Rossi, Lorenzo; Rosa, Manuela; Marceglia, Sara; Priori, Alberto.

In: Medical Engineering and Physics, Vol. 38, No. 5, 01.05.2016, p. 498-505.

Research output: Contribution to journalArticle

Arlotti, Mattia ; Rossi, Lorenzo ; Rosa, Manuela ; Marceglia, Sara ; Priori, Alberto. / An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson's Disease. In: Medical Engineering and Physics. 2016 ; Vol. 38, No. 5. pp. 498-505.
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