Abstract
Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule of about 7 mm diameter was removed from the scalp and diagnosed as a metastasis from thyroid cancer. After total thyroidectomy, a histological diagnosis of follicular thyroid cancer was made. Two cycles of radioactive iodine were performed. Both the follicular thyroid carcinoma (FTC) and the metastasis were investigated for the presence of BRAF/RAS and TERT promoter mutations. The results showed that the cutaneous metastasis was BRAF wild-type and TERT promoter-mutated (position g.1,295,228 C>T); in contrast, the primary thyroid lesion was negative for both molecular markers.
| Original language | English |
|---|---|
| Pages (from-to) | 513 |
| Journal | Frontiers in Endocrinology |
| Volume | 10 |
| DOIs | |
| Publication status | Published - 2019 |
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An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma. / Monti, Eleonora; Dono, Mariella; Gonella, Edoardo; Spina, Bruno; Pitto, Francesca; Petrogalli, Floriana; Conte, Lucia; Ambrosetti, Eleonora; Minuto, Michele N; Ansaldo, Gian Luca; Morbelli, Silvia; Zupo, Simona; Giusti, Massimo.
In: Frontiers in Endocrinology, Vol. 10, 2019, p. 513.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma
AU - Monti, Eleonora
AU - Dono, Mariella
AU - Gonella, Edoardo
AU - Spina, Bruno
AU - Pitto, Francesca
AU - Petrogalli, Floriana
AU - Conte, Lucia
AU - Ambrosetti, Eleonora
AU - Minuto, Michele N
AU - Ansaldo, Gian Luca
AU - Morbelli, Silvia
AU - Zupo, Simona
AU - Giusti, Massimo
PY - 2019
Y1 - 2019
N2 - Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule of about 7 mm diameter was removed from the scalp and diagnosed as a metastasis from thyroid cancer. After total thyroidectomy, a histological diagnosis of follicular thyroid cancer was made. Two cycles of radioactive iodine were performed. Both the follicular thyroid carcinoma (FTC) and the metastasis were investigated for the presence of BRAF/RAS and TERT promoter mutations. The results showed that the cutaneous metastasis was BRAF wild-type and TERT promoter-mutated (position g.1,295,228 C>T); in contrast, the primary thyroid lesion was negative for both molecular markers.
AB - Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule of about 7 mm diameter was removed from the scalp and diagnosed as a metastasis from thyroid cancer. After total thyroidectomy, a histological diagnosis of follicular thyroid cancer was made. Two cycles of radioactive iodine were performed. Both the follicular thyroid carcinoma (FTC) and the metastasis were investigated for the presence of BRAF/RAS and TERT promoter mutations. The results showed that the cutaneous metastasis was BRAF wild-type and TERT promoter-mutated (position g.1,295,228 C>T); in contrast, the primary thyroid lesion was negative for both molecular markers.
U2 - 10.3389/fendo.2019.00513
DO - 10.3389/fendo.2019.00513
M3 - Article
C2 - 31417495
VL - 10
SP - 513
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
ER -